106047-16-9

Basic information

• Product Name: Benzoic acid, 2-(4-pyridinyl)-, methyl ester
• CAS NO: 106047-16-9
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol File: 106047-16-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(4-pyridinyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(4-pyridinyl)-, methyl ester(106047-16-9)
• EPA Substance Registry System: Benzoic acid, 2-(4-pyridinyl)-, methyl ester(106047-16-9)

Safety Data

• Hazardous Substances Data: 106047-16-9(Hazardous Substances Data)

Upstream product

• 610-94-6 2-bromobenzoic acid methyl ester 
• 93830-58-1 diethyl (pyridin-4-yl)borane 
• 110-86-1 pyridine 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 63755-30-6 N-ethoxycarbonylpyridinium chloride 
• 93-58-3 benzoic acid methyl ester 
• 15854-87-2 4-iodopyridine 

Relevant articles and documents

Radical dearomatization of arenes and heteroarenes

The stannane-mediated benzeneselenol-catalyzed addition of aryl iodides to a range of arenes and aromatic hetereocycles has been studied. With furan, thiophene, and several carbocyclic arenes, the addition takes place with quenching of the adduct radical by the catalytic selenol leading to moderate yields of aryl-dihydroarenes. With nitrogen heterocycles, on the other hand, it was not possible to suppress aromatization of the adduct radical and fully aromatized products were isolated. Aryl iodides bearing hydrogen bond donating groups in the ortho-position add to nitrogen heterocycles with high selectivity ortho- to the nitrogen, affording a simple one-step synthesis of potential chelating ligands. While 2-iodophenol is an excellent aryl radical source in these reactions, the homologous 1-iodo-2-naphthol fails owing to its reaction with diphenyl diselenide, which gives 1-phenylseleno-2-naphthol in high yield.

A novel synthesis of 4-aryl- and 4-heteroarylpyridines via diethyl(4-pyridyl)borane

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Regioselective Addition ofd Copper-Zinc Aryl Organometallic Reagents to 3-substituted Pyridinium Salts

A number of 3-substituted pyridinium salts are subjected to nucleophilic addition by copper-zinc aryl organometallic reagents.The adducts are oxidized subsequently to form the corresponding 4-arylpyridines.In all the cases 1,4-addition products are obtained predominantly.The regioselectivity can be rationalized according to the hard-soft acid-base principle.Calculations on both charge distributions and FMO coefficients indicate that these reactions may be classified on the basis of the type of soft acid-soft base reactions.The observed γ-attack complies very well with the orientation of the FMO coefficients as estimated by a semiempirical method.