1057279-54-5

Basic information

• Product Name: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1057279-54-5
• Molecular Weight: 265.398
• Mol File: 1057279-54-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(1057279-54-5)
• EPA Substance Registry System: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(1057279-54-5)

Safety Data

• Hazardous Substances Data: 1057279-54-5(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 35779-04-5 1-tert-butyl-4-iodobenzene 

Downstream Products

• 1308790-35-3 2-(4-(tert-butyl)phenyl)-1-(2-methylallyl)-1,2,3,4-tetrahydroisoquinoline 
• 1391634-87-9 (S)-2-(2-(4-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde 
• 1616792-16-5 2-(2-(4-(tert-butyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-difluoro-1-phenylethanone 
• 1402732-48-2 1-(2-(4-(tert-butyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-propan-2-one 
• 1402732-40-4 1-(nitromethyl)-2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

Porphyrin-Catalyzed Oxidation of N-Substituted Tetrahydroisoquinolines to Dihydroisoquinolones

A visible-light-induced direct α-oxygenation of N-substituted 1,2,3,4-Tetrahydroisoquinoline derivatives has been successfully developed. Tetraphenylporphyrinatozinc(II) has been identified as an effective and inexpensive photocatalyst for this transformation with a wide range of substrates. This protocol provides a convenient route to the desired products in moderate to good yields at room temperature under air.

Radical alkylation of C(sp3)-H bonds with diacyl peroxides under catalyst-free conditions

Herein, we describe a protocol for alkylation reactions of C(sp3)-H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an α-Aminoalkyl radical. The mild, catalyst-And additive-free conditions make this protocol superior to previously reported C(sp3)-H alkylation strategies. The protocol was applied to 1,2,3,4-Tetrahydroisoquinolines and a tetrahydro-β-carboline derivative and could be carried out on a gram scale, indicating its utility for the alkylation of late-stage synthetic intermediates.