105454-25-9

Basic information

• Product Name: 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID
• Synonyms: 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID;BOC-3-(3-PYRIDYL)-DL-ALANINE;RARECHEM AK ML 0055;2-(tert-butoxycarbonylaMino)-3-(pyridin-3-yl)propanoic acid;3-Pyridinepropanoicacid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-(9CI)
• CAS NO: 105454-25-9
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.29
• Product Categories: pharmacetical
• Mol File: 105454-25-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 452.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.43±0.10(Predicted)
• CAS DataBase Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID(105454-25-9)
• EPA Substance Registry System: 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID(105454-25-9)

Safety Data

• Hazardous Substances Data: 105454-25-9(Hazardous Substances Data)

Usage

General Description

2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID is a chemical compound with the molecular formula C14H20N2O4. It is a derivative of pyridine and propionic acid, and contains a tert-butoxycarbonyl (Boc) protecting group. 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and other organic molecules. It is often utilized as a reagent in organic chemistry to introduce the pyridine-3-yl-propionic acid moiety into various molecules. Additionally, 2-TERT-BUTOXYCARBONYLAMINO-3-PYRIDIN-3-YL-PROPIONIC ACID may have potential applications in medicinal chemistry, particularly in the development of new drugs for various therapeutic purposes. Its unique structure and properties make it a valuable tool for researchers and chemists working in the field of organic synthesis and drug discovery.

Upstream product

• 102913-22-4 (4Z)-2-methyl-4((pyridin-3-yl)methylene)oxazol-5(4H)-one 
• 500-22-1 3-pyridinecarboxaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 70702-47-5 (2R)-2-amino-3-(pyridin-3-yl)propanoic acid 
• 17470-24-5 2-amino-3-(pyridin-3-yl)propanoic acid 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 89890-92-6 N-acetyl-(β-3-pyridyl)-α,β-dehydroalanine 
• 170092-30-5 N-acetyl-(β-3-pyridyl)-DL-alanine 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.

METHOD FOR SYNTHESIZING OPTICALLY ACTIVE a-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL] ACETAMIDE COMPOUND AND AMINO ACID

Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid. The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

Synthesis of low-hemolytic antimicrobial dehydropeptides based on gramicidin S

The synthesis and biological activity of a novel cyclic β-sheet-type antimicrobial dehydropeptide based on gramicidin S (GS) is described. The GS analogue, containing two (Z)-(β-3-pyridyl)-α,β-dehydroalanine (ΔZ3Pal) residues at the 4 and 4′ positions (2), was synthesized by solution-phase methodologies using Boc-Leu-ΔZ3Pal azlactone. Analogue 2 exhibited high antimicrobial activity against Gram-positive bacteria and had much lower hemolytic activity than wild-type GS and the corresponding (Z)-α,β-dehydrophenylalanine (ΔZ-Phe) analogue (1).