10486-08-5

Basic information

• Product Name: 4-METHYLBENZENETHIOL, SODIUM SALT
• Synonyms: SODIUM TOLYLMERCAPTONATE;4-METHYLBENZENETHIOL, SODIUM SALT;sodium toluene-p-thiolate;Benzenethiol, 4-methyl-, sodium salt;(4-Methylphenylthio) sodium;1-(Sodiothio)-4-methylbenzene;Sodium 4-methylbenzenethiolate;Sodium 4-methylphenylthiolate
• CAS NO: 10486-08-5
• Molecular Formula: C₇H₇NaS
• Molecular Weight: 146.19
• EINECS: 234-000-9
• Product Categories: Thiol/Mercaptan Salts;Organic Building Blocks;Sulfur Compounds
• Mol File: 10486-08-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 195°Cat760mmHg
• Flash Point: 69.5°C
• Appearance: White to off-white/Powder
• Density: g/cm³
• Vapor Pressure: 0.601mmHg at 25°C
• CAS DataBase Reference: 4-METHYLBENZENETHIOL, SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLBENZENETHIOL, SODIUM SALT(10486-08-5)
• EPA Substance Registry System: 4-METHYLBENZENETHIOL, SODIUM SALT(10486-08-5)

Safety Data

• RIDADR: UN 3335
• WGK Germany: 3
• Hazardous Substances Data: 10486-08-5(Hazardous Substances Data)

Usage

Uses

4-Methylbenzenethiol sodium salt is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H8S.Na/c1-6-2-4-7(8)5-3-6;/h2-5,8H,1H3;/q;+1/p-1

Upstream product

• 106-45-6 para-thiocresol 
• 1310-73-2 sodium hydroxide 
• 103-19-5 di(p-tolyl) disulfide 
• 811-98-3 d⁽⁴⁾-methanol 
• 53492-47-0 3-<2-<(4-methylphenyl)thio>ethyl>-4-methylsydnone 

Downstream Products

• 855290-54-9 4-nitro-2-p-tolylsulfanyl-benzonitrile 
• 855290-55-0 2-nitro-4-p-tolylsulfanyl-benzonitrile 
• 20114-05-0 2,4-dinitrobenzene p-methylbenzene sulfide 
• 85169-05-7 3-[(4-methylphenyl)sulfanyl]propanoic acid ethyl ester 
• 32631-21-3 (2-chloro-4-nitro-phenyl)-p-tolyl sulfide 
• 19062-76-1 (1-phenyl-2-tosylethyl)-(p-tolyl)sulfane 
• 856060-74-7 (2,6-diiodo-4-nitro-phenyl)-p-tolyl sulfide 
• 860226-89-7 1,3-dimethyl-7-(2-p-tolylmercapto-ethyl)-3,7-dihydro-purine-2,6-dione 
• 857621-06-8 acetic acid-(2-nitro-3,5-bis-p-tolylsulfanyl-anilide) 
• 100716-85-6 4-chlorobenzyl 4-methylphenyl sulfide 
• 107682-42-8 p-tolyl-(2,4,5-trichloro-benzyl)-sulfide 
• 33597-89-6 4-methylphenyl prop-2'-ynyl sulfide 
• 93351-13-4 1-ethoxy-1-p-tolylsulfanyl-ethene 
• 175278-42-9 5-nitro-2-p-tolylsulfanyl-benzaldehyde 

Relevant articles and documents

Nucleophilic Reactivities of Thiophenolates

The nucleophilic reactivities of substituted thiophenolates were determined by following the kinetics of their reactions with a series of quinone methides (reference electrophiles) in DMSO at 20 °C. The experimentally determined second-order rate constants were analyzed according to the Mayr-Patz equation log k = sN(N + E) to derive the nucleophile-specific reactivity parameters N and sN for ten thiophenolate ions.

NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, a diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.

N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-positions

Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: STR1 wherein X is --S--, --S(O)-- or --S(O)2 --; A is a loweralkalene chain and A1 and A2 are alkalene chains when p and d are one; R, R1 and R2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R1 and R2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed. Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with --(A2)p --X--(A2)d --Q side chain are also disclosed.