1044569-46-1 Usage
Description
Ophthazin Impurity 2 is a chemical impurity commonly found in ophthalmic products, categorized as a potential impurity in drugs and pharmaceuticals. It is included in the list of impurities that need to be monitored and controlled during the manufacturing process due to its potential adverse effects on the human body.
Uses
Ophthazin Impurity 2 does not have any known beneficial uses in any industry. Its presence in ophthalmic products is undesirable, and strict regulations and guidelines are in place to limit its presence to ensure the safety and efficacy of these products. Manufacturers and regulatory authorities must closely monitor and control the levels of Ophthazin Impurity 2 in ophthalmic products.
Check Digit Verification of cas no
The CAS Registry Mumber 1044569-46-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,4,5,6 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1044569-46:
(9*1)+(8*0)+(7*4)+(6*4)+(5*5)+(4*6)+(3*9)+(2*4)+(1*6)=151
151 % 10 = 1
So 1044569-46-1 is a valid CAS Registry Number.
1044569-46-1Relevant articles and documents
Kinetic study of the reaction of pyridoxal 5'-phosphate with hydrazino compounds of pharmacological activity
Echevarria-Gorostidi,Basagoitia,Pizarro,Goldsmid,Blanco,Blanco
, p. 837 - 844 (1998)
The kinetics of the reaction between pyridoxal 5'-phosphate (PLP) with carbidopa, hydralazine, and isoniazid, in aqueous solution at variable pH and constant ionic strength of 0.1M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base, and its stability were determined in a wide range of pH. A comparison is made of the formation rate constants with those of PLP with hydrazine. The reactivity shows the sequence isoniazid > hydrazine > carbidopa > hydralazine in the whole range of pH studied. The Schiff bases studied are more stable than those formed by PLP and hexylamine and as stable as those described for the reactions of PLP with poly(L-lysine) or copolypeptides containing L-lysine.