10357-04-7

Basic information

• Product Name: 4-methoxy-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one
• CAS NO: 10357-04-7
• Molecular Formula: C₁₁H₁₆N₂O₆
• Molecular Weight: 272.2545
• Mol File: 10357-04-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 485.4°C at 760 mmHg
• Flash Point: 247.4°C
• Density: 1.61g/cm³
• Vapor Pressure: 1.85E-11mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 4-methoxy-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one(10357-04-7)
• EPA Substance Registry System: 4-methoxy-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one(10357-04-7)

Safety Data

• Hazardous Substances Data: 10357-04-7(Hazardous Substances Data)

Relevant articles and documents

Reaction products from N methyl N nitrosorea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4 methylthymidine

DNA was treated with N methyl N nitrosourea at pH 7-8, 37°C, degraded to yield 3 and 7 methylpurines and deoxyribonucleosides and the reaction products were separated by chromatography on ion exchange resins. The following methods for identification and determination of products were used: with unlabelled N methyl N nitrosourea, u.v. absorption; use of methyl 14C labelled N methyl N nitrosourea and use of [14C]thymine labelled DNA. The synthesis of O4 methylthymidine and its identification by u.v. and mass spectroscopy are reported. 3 Methylthymidine and O4 methylthymidine were found as methylation products from N methyl N nitrosourea with thymidine and with DNA, in relatively small yields. Unidentified products containing thymine were found in enzymic digests of N methyl N nitrosourea treated DNA, which may be phosphotriesters.