103547-97-3

Basic information

• Product Name: 2-Propenoic acid, 2-(bromomethyl)-3-phenyl-, methyl ester, (Z)-
• CAS NO: 103547-97-3
• Molecular Formula: C11H11BrO2
• Molecular Weight: 255.111
• Mol File: 103547-97-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-(bromomethyl)-3-phenyl-, methyl ester, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(bromomethyl)-3-phenyl-, methyl ester, (Z)-(103547-97-3)
• EPA Substance Registry System: 2-Propenoic acid, 2-(bromomethyl)-3-phenyl-, methyl ester, (Z)-(103547-97-3)

Safety Data

• Hazardous Substances Data: 103547-97-3(Hazardous Substances Data)

Upstream product

• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 100-52-7 benzaldehyde 

Downstream Products

• 53059-48-6 2-(morpholin-4-yl-phenyl-methyl)-acrylic acid methyl ester 
• 53059-61-3 2-morpholin-4-ylmethyl-3-phenyl-acrylic acid methyl ester 
• 86318-59-4 α-(tert-Butylthioethinylthiomethyl)zimtsaeure-methylester 
• 105400-43-9 (4,5-cis)-3-methylene-4,5-diphenyldihydrofuran-2(3H)-one 
• 1141874-21-6 C₂₂H₂₁NO₆ 
• 1141874-20-5 C₂₃H₂₃NO₆ 
• 1141874-19-2 C₂₂H₂₁NO₆ 
• 1141874-47-6 C₂₁H₂₁NO₄ 
• 1141874-48-7 C₂₁H₂₁NO₄ 
• 1141874-50-1 C₁₇H₁₇NO₂ 
• 1141874-52-3 methyl 2-methylene-3-phenyl-4-(pyridin-2-yl)butanoate 
• 1159004-81-5 (E)-methyl 2-[(2-formyl-1H-pyrrol-1-yl)methyl]-3-phenylacrylate 
• 1170354-28-5 C₁₈H₁₈BrNO₂ 
• 1170354-50-3 C₂₅H₂₄BrNO₄S 

Relevant articles and documents

Synthesis, in vitro, and in vivo evaluation of novel functionalized quaternary ammonium curcuminoids as potential anti-cancer agents

Novel functionalized quaternary ammonium curcuminoids have been synthesized from piperazinyl curcuminoids and Baylis-Hillman reaction derived allyl bromides. These molecules are found to be highly water soluble with increased cytotoxicity compared to native curcumin against three cancer cell lines MIAPaCa-2, MDA-MB-231, and 4T1. Preliminary in vivo toxicity evaluation of a representative curcuminoid 5a in healthy mice indicates that this molecule is well tolerated based on normal body weight gains compared to control group. Furthermore, the efficacy of 5a has been tested in a pancreatic cancer xenograft model of MIAPaCa-2 and has been found to exhibit good tumor growth inhibition as a single agent and also in combination with clinical pancreatic cancer drug gemcitabine.

COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY

The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof.

Halodeboronation of organotrifluoroborates using tetrabutylammonium tribromide or cesium triiodide

Halodeboronation of organotrifluoroborates using commercially available tetrabutylammonium tribromide (TBATB) or cesium triiodide in aqueous medium is reported. The mild, transition metal-free method has proven to be tolerant of a wide range of functional groups. High regio- and chemoselectivity are observed. Two synthetic routes to (Z)-dibromoalkenes from alkynes, through stereodefined (Z)-2-bromoalkenyltrifluoroborates and (Z)-1,2-bis(boryl) alkenyltrifluoroborates, have been developed using the TBATB mediated bromodeboronation as the key step.