1035173-74-0 Usage
Description
1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE, also known as Benzyl 3-(Chlorosulfonyl)pyrrolidine-1-carboxylate, is a chemical compound with the molecular formula C12H16ClNO4S. It is a derivative of pyrrolidine, featuring a chlorosulfonyl group at the 3-position and a carboxylate group at the 1-position, which is protected by a benzyl group. 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE is known for its reactivity and potential applications in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE is used as a reactant in the preparation of sulfonamide analogs of phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474. PI3K inhibitors are a class of drugs that target the PI3K/Akt/mTOR signaling pathway, which plays a crucial role in cell growth, survival, and metabolism. By inhibiting this pathway, these drugs can potentially treat various diseases, including cancer and inflammatory disorders.
In the synthesis of ZSTK474 analogs, 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE serves as a key intermediate, providing a versatile platform for the development of novel PI3K inhibitors with improved potency, selectivity, and pharmacokinetic properties. The use of this compound in the pharmaceutical industry highlights its importance in the discovery and development of new therapeutic agents targeting the PI3K/Akt/mTOR signaling pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 1035173-74-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,1,7 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1035173-74:
(9*1)+(8*0)+(7*3)+(6*5)+(5*1)+(4*7)+(3*3)+(2*7)+(1*4)=120
120 % 10 = 0
So 1035173-74-0 is a valid CAS Registry Number.
1035173-74-0Relevant articles and documents
ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF
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, (2020/04/25)
A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.
SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS
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Page/Page column 164-165, (2008/12/06)
A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus
