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1034439-43-4

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1034439-43-4 Usage

Uses

An impurity of Donepezil.

Check Digit Verification of cas no

The CAS Registry Mumber 1034439-43-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,4,3 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1034439-43:
(9*1)+(8*0)+(7*3)+(6*4)+(5*4)+(4*3)+(3*9)+(2*4)+(1*3)=124
124 % 10 = 4
So 1034439-43-4 is a valid CAS Registry Number.

1034439-43-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride

1.2 Other means of identification

Product number -
Other names 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane Hydrochloride (Donepezil Impurity)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1034439-43-4 SDS

1034439-43-4Relevant articles and documents

Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation

Camps, Pelayo,Formosa, Xavier,Galdeano, Carles,Gómez, Tània,Mu?oz-Torrero, Diego,Scarpellini, Michele,Viayna, Elisabet,Badia, Albert,Clos, M. Victòria,Camins, Antoni,Pallàs, Mercè,Bartolini, Manuela,Mancini, Francesca,Andrisano, Vincenza,Estelrich, Joan,Lizondo, Mònica,Bidon-Chanal, Axel,Luque, F. Javier

supporting information; experimental part, p. 3588 - 3598 (2009/05/30)

A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced Aβ aggregation. These compounds consist of a unit of tacrine or 6-chlorotacrine, which occupies the same position as tacrine at the AChE active site, and the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone moiety of donepezil (or the indane derivative thereof), whose position along the enzyme gorge and the peripheral site can be modulated by a suitable tether that connects tacrine and donepezil fragments. All of the new compounds are highly potent inhibitors of bovine and human AChE and BChE, exhibiting IC50 values in the subnanomolar or low nanomolar range in most cases. Moreover, six out of the eight hybrids of the series, particularly those bearing an indane moiety, exhibit a significant Aβ antiaggregating activity, which makes them promising anti-Alzheimer drug candidates.

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