1032564-18-3 Usage
Description
N-acetic acid-1-aMino-3-adaMantanol, also known as N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycine, is a chemical compound with a unique molecular structure. It is an impurity found in Vildagliptin, which is an oral anti-hyperglycemic agent used to inhibit dipeptidyl peptidase 4 (DPP-4). N-acetic acid-1-aMino-3-adaMantanol has potential applications in various industries due to its specific properties.
Uses
Used in Pharmaceutical Industry:
N-acetic acid-1-aMino-3-adaMantanol is used as an impurity in the production of Vildagliptin (V305000) for the treatment of type 2 diabetes. It plays a role in the development and formulation of this class of oral anti-hyperglycemic agents, which inhibit DPP-4, a serine exopeptidase, to help regulate blood sugar levels in patients.
Used in Research and Development:
N-acetic acid-1-aMino-3-adaMantanol can be utilized as a research compound for studying the properties and effects of Vildagliptin and other DPP-4 inhibitors. This can lead to the development of new drugs or improved formulations with better efficacy and fewer side effects.
Used in Quality Control and Analysis:
As an impurity in Vildagliptin, N-acetic acid-1-aMino-3-adaMantanol is important for quality control and analysis in the pharmaceutical industry. Ensuring the purity and consistency of the final product is crucial for its safety and effectiveness. N-acetic acid-1-aMino-3-adaMantanol can be used as a reference material for analytical methods and testing procedures.
Check Digit Verification of cas no
The CAS Registry Mumber 1032564-18-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,2,5,6 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1032564-18:
(9*1)+(8*0)+(7*3)+(6*2)+(5*5)+(4*6)+(3*4)+(2*1)+(1*8)=113
113 % 10 = 3
So 1032564-18-3 is a valid CAS Registry Number.
1032564-18-3Relevant articles and documents
Synthetic method of vildagliptin
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Paragraph 0070; 0072; 0092; 0112; 0128, (2017/09/01)
The invention relates to the technical field of drug synthesis and particularly relates to a synthetic method of vildagliptin. The synthetic method comprises the following steps: carrying out imino group protection and acylamino dehydration on a starting raw material, namely L-prolinamide, and carrying out deproteciton salification by virtue of p-toluene sulfonic acid so as to obtain p-toluenesulfonate of (S)-2-cyanopyrrolidine; substituting and hydrolyzing 3-amino-1-adamantanol so as to obtain 3-iminoacetic acid-1-adamantanol; carrying out condensation acylation by virtue of 3-iminoacetic acid-1-adamantanol and (S)-2-cyanopyrrolidine under the action of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, so as to obtain the vildagliptin. The synthetic method has the beneficial effects that reaction conditions are mild, an intermediate does not absorb moisture and is easy to store, the purity of the synthesized vildagliptin is high and is more than or equal to 99.50%, and the maximum single impurity content is less than or equal to 0.10%.
PROCESS FOR PREPARATION OF DPP-IV INHIBITORS
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Page/Page column 17-18, (2011/09/19)
Process for the preparation of DPP-IV inhibitors, such as 1-[[(3-hydroxy-1-adamantyl) amino] acetyl]-2-cyano-(S)-pyrrolidine are disclosed.
