1029713-99-2Relevant articles and documents
Preparation method of capmatinib
-
Paragraph 0034-0037, (2020/11/09)
The invention provides a preparation method of capmatinib. The inventor carries out wide and deep research, massive screening and testing. A compound represented by a formula III is adopted as the rawmaterial for hydrolysis reaction and methylation reaction to obtain a formula I compound, namely capmatinib. The method is mild in reaction condition, environment-friendly, low in energy consumption,good in product purity and high in yield, and is suitable for industrial large-scale production.