10276-09-2Relevant articles and documents
An oxidative approach to a hydroxypiperidinone utilizing a Rh-catalyzed C-H activation process
Ayers, Timothy A.
, p. 1415 - 1418 (2013)
C-H activation and isomerization using a Rh-catalyst provided quick access to dehydropiperidine derivatives that could be further oxidized to hydroxypiperidinone derivatives.
Total Synthesis of the Potent HIF-1 Inhibitory Antitumor Natural Product, (8R)-Mycothiazole, via Baldwin-Lee CsF/CuI sp3-sp2-Stille Cross-Coupling. Confirmation of the Crews Reassignment
Wang, Liping,Hale, Karl J.
, p. 4200 - 4203 (2015)
A convenient asymmetric total synthesis of the potent HIF-1 inhibitory antitumor natural product, (-)- or (+)-(8R)-mycothiazole (1), is described. Not only does our synthesis confirm the 2006 structural reassignment made by Crews (Crews, P., et al. J. Nat
Caesium fluoride-mediated hydrocarboxylation of alkenes and allenes: Scope and mechanistic insights
Gevorgyan, Ashot,Obst, Marc F.,Guttormsen, Yngve,Maseras, Feliu,Hopmann, Kathrin H.,Bayer, Annette
, p. 10072 - 10078 (2019/11/14)
A caesium fluoride-mediated hydrocarboxylation of olefins is disclosed that does not rely on precious transition metal catalysts and ligands. The reaction occurs at atmospheric pressures of CO2 in the presence of 9-BBN as a stoichiometric reductant. Stilbenes, β-substituted styrenes and allenes could be carboxylated in good yields. The developed methodology can be used for preparation of commercial drugs as well as for gram scale hydrocarboxylation. Computational studies indicate that the reaction occurs via formation of an organocaesium intermediate.
Preferential Photoreaction in a Porous Crystal, Metal-Macrocycle Framework: PdII-Mediated Olefin Migration over [2+2] Cycloaddition
Yonezawa, Hirotaka,Tashiro, Shohei,Shiraogawa, Takafumi,Ehara, Masahiro,Shimada, Rintaro,Ozawa, Takeaki,Shionoya, Mitsuhiko
supporting information, p. 16610 - 16614 (2018/12/11)
A nanosized confined space with well-defined functional surfaces has great potential to control the efficiency and selectivity of catalytic reactions. Herein we report that a 1,6-diene, which normally forms an intramolecular [2+2] cycloadduct under photoirradiation, preferentially undergoes a photoinduced olefin migration in a porous crystal, metal-macrocycle framework (MMF), and alternatively [2+2] cycloaddition is completely inhibited in the confined space. A plausible reaction mechanism for olefin migration triggered by the photoinduced dissociation of the Pd-Cl bond is suggested based on UV-vis diffuse reflectance spectroscopy, single-crystal XRD, and MS-CASPT2 calculation. The substrate scope of the photoinduced olefin migration in MMF was also examined using substituted allylbenzene derivatives.
KINASE INHIBITORS AND USES THEREOF
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Paragraph 0256; 0342, (2018/12/13)
The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
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Paragraph 0269, (2017/08/01)
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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Page/Page column 722; 723, (2015/02/02)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Carboxylation of organoboronic esters with potassium methyl carbonate under copper catalysis
Duong, Hung A.,Nguyen, Tuan Minh,Rosman, Nurul Zubaidah Binte,Tan, Lionel Jia Liang
, p. 1881 - 1885 (2014/07/22)
In the presence of a copper catalyst, potassium methyl carbonate serves as a versatile carboxylating agent of allyl- and arylboronic esters for the preparation of carboxylic acids. Georg Thieme Verlag Stuttgart New York.
MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
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Page/Page column 90, (2014/01/08)
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
Regioselective copper-catalyzed carboxylation of allylboronates with carbon dioxide
Duong, Hung A.,Huleatt, Paul B.,Tan, Qian-Wen,Shuying, Eileen Lau
supporting information, p. 4034 - 4037 (2013/09/02)
In the presence of a Cu(I)/NHC catalyst, the reactions of allylboronic pinacol esters with CO2 (1 atm) are highly regioselective, giving exclusively the more substituted β,γ-unsaturated carboxylic acids in most cases. A diverse array of substituted carboxylic acids can be prepared via this method, including compounds featuring all-carbon quaternary centers.
