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1027345-15-8

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1027345-15-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1027345-15-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,7,3,4 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1027345-15:
(9*1)+(8*0)+(7*2)+(6*7)+(5*3)+(4*4)+(3*5)+(2*1)+(1*5)=118
118 % 10 = 8
So 1027345-15-8 is a valid CAS Registry Number.

1027345-15-8Downstream Products

1027345-15-8Relevant articles and documents

Dihydroquinone derivatives of piperidine and piperazine

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Page/Page column 10-11, (2015/01/07)

The dihydroquinone derivatives of piperidine and piperazine are 7-piperazinyl and 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones that exhibit D2 and 5-HT1A receptor binding affinities, making them suitable for use as the active ingre

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Sleebs, Brad E.,Czabotar, Peter E.,Fairbrother, Wayne J.,Fairlie, W. Douglas,Flygare, John A.,Huang, David C. S.,Kersten, Wilhelmus J. A.,Koehler, Michael F. T.,Lessene, Guillaume,Lowes, Kym,Parisot, John P.,Smith, Brian J.,Smith, Morey L.,Souers, Andrew J.,Street, Ian P.,Yang, Hong,Baell, Jonathan B.

experimental part, p. 1914 - 1926 (2011/05/30)

ABT-737 and ABT-263 are potent inhibitors of the BH3 antiapoptotic proteins, Bcl-xL and Bcl-2. This class of putative anticancer agents invariantly contains an acylsulfonamide core. We have designed and synthesized a series of novel quinazoline-based inhibitors of Bcl-2 and Bcl-xL that contain a heterocyclic alternative to the acylsulfonamide. These compounds exhibit submicromolar, mechanism-based activity in human small-cell lung carcinoma cell lines in the presence of 10% human serum. This comprises the first successful demonstration of a quinazoline sulfonamide core serving as an effective benzoylsulfonamide bioisostere. Additionally, these novel quinazolines comprise only the second known class of Bcl-2 family protein inhibitors to induce mechanism-based cell death.

ARYLSULFONAMIDE COMPOUNDS

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Page/Page column 40; 49, (2008/12/05)

The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim

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