102237-68-3

Basic information

• Product Name: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone
• Synonyms: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone
• CAS NO: 102237-68-3
• Molecular Weight: 305.376
• Mol File: 102237-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone(102237-68-3)
• EPA Substance Registry System: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone(102237-68-3)

Safety Data

• Hazardous Substances Data: 102237-68-3(Hazardous Substances Data)

Upstream product

• 83-24-9 2,5-dimethyl-1-phenyl-1H-pyrrole 
• 100-07-2 4-methoxy-benzoyl chloride 
• 201230-82-2 carbon monoxide 
• 66107-29-7 4-methoxyphenyl triflate 

Relevant articles and documents

Palladium catalyzed carbonylative generation of potent, pyridine-based acylating electrophiles for the functionalization of arenes to ketones

We describe here the design of a palladium catalyzed route to generate aryl ketones via the carbonylative coupling of (hetero)arenes and aryl- or vinyl-triflates. In this, the use of the large bite angle Xantphos ligand on palladium provides a unique avenue to balance the activation of the relatively strong C(sp2)-OTf bond with the ultimate elimination of a new class of potent Friedel-Crafts acylating agent: N-acyl pyridinium salts. The latter can be exploited to modulate reactivity and selectivity in carbonylative arene functionalization chemistry, and allow the efficient synthesis of ketones with a diverse array of (hetero)arenes. This journal is