Welcome to LookChem.com Sign In|Join Free

CAS

  • or

10212-20-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • Factory Price API 99% 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 10212-20-1 GMP Manufacturer

    Cas No: 10212-20-1

  • USD $ 0.1-0.1 / Gram

  • 1 Gram

  • 100 Metric Ton/Year

  • Xi'an Xszo Chem Co., Ltd.
  • Contact Supplier
  • 10212-20-1 Structure
  • Basic information

    1. Product Name: 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
    2. Synonyms: 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE;2'-FLUORO-D-CYTIDINE;2'-DEOXY-2'-FLUOROCYTIDINE;2'-FC;2'-FLUORO-2'-DEOXYCYTIDINE;2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC);2'-Deoxy-2'-fluoro-D-cytidine
    3. CAS NO:10212-20-1
    4. Molecular Formula: C9H12FN3O4
    5. Molecular Weight: 245.21
    6. EINECS: 1806241-263-5
    7. Product Categories: Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents
    8. Mol File: 10212-20-1.mol
    9. Article Data: 27
  • Chemical Properties

    1. Melting Point: 167 °C
    2. Boiling Point: 500.1 °C at 760 mmHg
    3. Flash Point: 256.2 °C
    4. Appearance: White to Off-white/Powder
    5. Density: 1.82 g/cm3
    6. Refractive Index: 80 ° (C=1, MeOH)
    7. Storage Temp.: 2-8°C
    8. Solubility: Soluble in DMSO, Methanol.
    9. PKA: 12.84±0.70(Predicted)
    10. CAS DataBase Reference: 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)
    12. EPA Substance Registry System: 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 10212-20-1(Hazardous Substances Data)

10212-20-1 Usage

Description

4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one is a complex organic compound characterized by its unique molecular structure, featuring a pyrimidin-2-one core with an amino group at the 4-position and a fluorinated oxolan-2-yl moiety at the 1-position. This white solid exhibits potent antiviral properties, making it a promising candidate for pharmaceutical applications.

Uses

Used in Antiviral Applications:
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one is used as an antiviral agent for inhibiting the replication and spread of various viruses, including the hepatitis C virus and the Borna Disease virus. Its potent inhibitory effects on viral replicons in Huh-7 cells demonstrate its potential as a therapeutic agent in combating viral infections.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one is used as a key intermediate in the synthesis of antiviral drugs. Its unique chemical properties and antiviral activity make it a valuable component in the development of new medications to treat viral diseases.
Used in Research and Development:
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one is also used in research and development for studying the mechanisms of viral replication and the development of resistance to antiviral drugs. Its potent inhibitory effects on viral replicons provide valuable insights into the design of new antiviral agents and strategies for combating viral infections.

Check Digit Verification of cas no

The CAS Registry Mumber 10212-20-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,1 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10212-20:
(7*1)+(6*0)+(5*2)+(4*1)+(3*2)+(2*2)+(1*0)=31
31 % 10 = 1
So 10212-20-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6?,7-,8-/m1/s1

10212-20-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D3614)  2'-Deoxy-2'-fluorocytidine Hydrate  >98.0%(T)

  • 10212-20-1

  • 1g

  • 790.00CNY

  • Detail

10212-20-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2'-Deoxy-2'-fluorocytidine

1.2 Other means of identification

Product number -
Other names 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10212-20-1 SDS

10212-20-1Synthetic route

9-<2-deoxy-2-fluoro-3,5-di-O-(tetrahydropyran-2-yl)-β-D-ribofuranosyl>cytosine
157024-78-7

9-<2-deoxy-2-fluoro-3,5-di-O-(tetrahydropyran-2-yl)-β-D-ribofuranosyl>cytosine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With ethanol; pyridinium p-toluenesulfonate for 24h; Heating;66%
3',5'-Di-O-benzoyl-2'-desoxy-2'-fluorcytidin

3',5'-Di-O-benzoyl-2'-desoxy-2'-fluorcytidin

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With ammonium hydroxide at 50℃;56%
Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-tetrahydro-furan-3-yl ester

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With N,N-dimethyl-ethanamine In methanol at 50℃; for 24h; Yield given;
cyclocitidine
31698-14-3

cyclocitidine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With potassium fluoride
3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine
10212-13-2

3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (PhO)2POCl, Et3N / acetonitrile / 1.5 h / Ambient temperature
2: 32percent aq. NH3 / dioxane / 0.33 h
3: EtNMe2 / methanol / 24 h / 50 °C
View Scheme
2'-deoxy-2'-fluorouridine
56287-17-3, 69123-94-0, 784-71-4

2'-deoxy-2'-fluorouridine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / pyridine / 2 h / Ambient temperature
2: (PhO)2POCl, Et3N / acetonitrile / 1.5 h / Ambient temperature
3: 32percent aq. NH3 / dioxane / 0.33 h
4: EtNMe2 / methanol / 24 h / 50 °C
View Scheme
Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-4-fluoro-5-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester
196928-90-2

Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-4-fluoro-5-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 32percent aq. NH3 / dioxane / 0.33 h
2: EtNMe2 / methanol / 24 h / 50 °C
View Scheme
2,2'-Anhydrouridine
3736-77-4

2,2'-Anhydrouridine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 87 percent / p-TsOH / dimethylformamide / 2.5 h / 0 °C
2: 25.1 g / 1 N aq. NaOH / methanol / 1.5 h / Ambient temperature
3: 57 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH2Cl2 / 3 h / Heating
4: 1.) 4-chlorophenyl phosphorodichloridate, 1,2,4-triazole, pyridine, 2.) conc. NH4OH / 1.) RT, 2 d, 2.) dioxane, RT, 1 d
5: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / Heating
View Scheme
3',5'-di-O-(tetrahydropyran-2-yl)-2,2'-O-cyclouridine
351523-07-4

3',5'-di-O-(tetrahydropyran-2-yl)-2,2'-O-cyclouridine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 25.1 g / 1 N aq. NaOH / methanol / 1.5 h / Ambient temperature
2: 57 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH2Cl2 / 3 h / Heating
3: 1.) 4-chlorophenyl phosphorodichloridate, 1,2,4-triazole, pyridine, 2.) conc. NH4OH / 1.) RT, 2 d, 2.) dioxane, RT, 1 d
4: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / Heating
View Scheme
9-<3,5-di-O-(tetrahydropyran-2-yl)-β-D-arabinofuranosyl>uracil
157024-75-4

9-<3,5-di-O-(tetrahydropyran-2-yl)-β-D-arabinofuranosyl>uracil

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 57 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH2Cl2 / 3 h / Heating
2: 1.) 4-chlorophenyl phosphorodichloridate, 1,2,4-triazole, pyridine, 2.) conc. NH4OH / 1.) RT, 2 d, 2.) dioxane, RT, 1 d
3: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / Heating
View Scheme
9-<2-deoxy-2-fluoro-3,5-di-O-(tetrahydropyran-2-yl)-β-D-ribofuranosyl>uracil
157024-77-6

9-<2-deoxy-2-fluoro-3,5-di-O-(tetrahydropyran-2-yl)-β-D-ribofuranosyl>uracil

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) 4-chlorophenyl phosphorodichloridate, 1,2,4-triazole, pyridine, 2.) conc. NH4OH / 1.) RT, 2 d, 2.) dioxane, RT, 1 d
2: 66 percent / pyridinium p-toluenesulfonate (PPTS), C2H5OH / 24 h / Heating
View Scheme
3',5'-Di-o-benzoyl-2'-desoxy-2'-fluoruridin

3',5'-Di-o-benzoyl-2'-desoxy-2'-fluoruridin

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 73 percent / p-Cl-C6H4-OP(O)Cl2
2: 82 percent / conc. aq. NH3 / dioxane / 1 h
3: 56 percent / conc. NH3 / 50 °C
View Scheme
4-Tetrazolo-3',5'-di-O-benzoyl-2'-fluor-1(2H)-pyrimidinon
128963-08-6

4-Tetrazolo-3',5'-di-O-benzoyl-2'-fluor-1(2H)-pyrimidinon

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / conc. aq. NH3 / dioxane / 1 h
2: 56 percent / conc. NH3 / 50 °C
View Scheme
benzoic acid anhydride
93-97-0

benzoic acid anhydride

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

N4-benzoyl-2-deoxy-2-fluorocytidine
146954-76-9

N4-benzoyl-2-deoxy-2-fluorocytidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃;100%
In N,N-dimethyl-formamide at 20℃;100%
In N,N-dimethyl-formamide92%
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

5-bromo-2'-deoxy-2'-fluorocytidine

5-bromo-2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With pyridine; bromine In tetrachloromethane at 20℃; for 0.416667h;84%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

2'-deoxy-2'-fluoro-5'-O-TBDMS-cytidine
1246253-27-9

2'-deoxy-2'-fluoro-5'-O-TBDMS-cytidine

Conditions
ConditionsYield
With pyridine at 20℃;82%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 4h; regioselective reaction;77%
With pyridine at 20℃; for 16h; Cooling with ice;
With pyridine
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

5-iodo-2'-deoxy-2'-(R)-fluoro-cytidine
80791-93-1

5-iodo-2'-deoxy-2'-(R)-fluoro-cytidine

Conditions
ConditionsYield
With iodine; 3-chloro-benzenecarboperoxoic acid In N,N-dimethyl-formamide at 20℃; for 7h;67%
With Iodine monochloride In methanol at 50℃; for 4h;39%
With iodine; iodic acid; acetic acid In tetrachloromethane; water at 45℃; for 4h; Iodination;
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

2'-deoxy-2'-fluoro-N4-hydroxycytidine

2'-deoxy-2'-fluoro-N4-hydroxycytidine

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium hydroxide In water at 55℃; for 16h; pH=5; Inert atmosphere;47%
With hydroxylamine hydrochloride In water at 55℃; for 16h; pH=5; Sealed tube; Inert atmosphere;91 mg
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

5-chloro-2'-deoxy-2'-fluorocytidine

5-chloro-2'-deoxy-2'-fluorocytidine

Conditions
ConditionsYield
With benzoyl chloride; 3-chloro-benzenecarboperoxoic acid In N,N-dimethyl-formamide at 20℃; for 0.5h;24%
acetyl chloride
75-36-5

acetyl chloride

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-tetrahydro-furan-3-yl ester; hydrochloride

Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-tetrahydro-furan-3-yl ester; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90 - 95℃; for 0.5h;
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

2,6-diaminopurine
1904-98-9

2,6-diaminopurine

2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine
134444-47-6

2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine

Conditions
ConditionsYield
With E. coli BMT-4D Substitution;
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

N-{3-[4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide

N-{3-[4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HIO3; I2; AcOH / CCl4; H2O / 4 h / 45 °C
2: CuI; (Ph3P)4P; Et3N / dimethylformamide / 16 h
View Scheme
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

2'-deoxy-2'-fluoroguanosine
78842-13-4

2'-deoxy-2'-fluoroguanosine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: E. coli BMT-4D/1A
2: ADase
View Scheme
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine
146954-77-0

N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / dimethylformamide
2: 87 percent / Et3N / pyridine
View Scheme
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

N4-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(β-cyanoethyl N,N-diisopropylphosphoramidite)
161442-19-9

N4-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-(β-cyanoethyl N,N-diisopropylphosphoramidite)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / dimethylformamide
2: 87 percent / Et3N / pyridine
3: 90 percent / (i-Pr)2EtN / CH2Cl2
View Scheme
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

3',5'-di-O-acetyl-2'-deoxy-2'-fluoro-5-iodocytosine hydrochloride
83966-99-8

3',5'-di-O-acetyl-2'-deoxy-2'-fluoro-5-iodocytosine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) HCl / 0.5 h / 90 - 95 °C
2: I2, HIO3, AcOH / H2O; CCl4 / 24 h / 50 - 55 °C
View Scheme
2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

N4-benzoyl-2-deoxy-2-fluorocytidine
146954-76-9

N4-benzoyl-2-deoxy-2-fluorocytidine

2'-deoxy-2'-fluorocytidine
10212-20-1

2'-deoxy-2'-fluorocytidine

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

C25H30FN3O4Si

C25H30FN3O4Si

Conditions
ConditionsYield
With dmap; triethylamine In N,N-dimethyl-formamide at 0 - 50℃; for 12h;

10212-20-1Relevant articles and documents

Synthesis and hypnotic and anti-human immunodeficiency virus-1 activities of N3-substituted 2'-deoxy-2'-fluorouridines

Sato,Utsumi,Maruyama,Kimura,Yamamoto,Richman

, p. 595 - 598 (1994)

Reaction of 9-[3,5-di-O-(tetrahydropyran-2-yl)-β-D- arabinofuranosyl]uracil (2) with diethylaminosulfur trifluoride in the presence of pyridine afforded 2'-deoxy-2'-flouroriboside 3a, from which 2'- deoxy-2'-fluorocytidine (14b) has been synthesized in good yield. Compound 3a was deprotected and subsequently treated with various benzyl halides or 2- chloro-4-fluoroacetophenone to give corresponding N3-substituted 2'-deoxy- 2'-fluorouridines 5a-c and 6. Compounds 5a-c, as well as 6, showed weak hypnotic activity in mice. Compound 4b showed moderate antiviral activity against human immunodeficiency virus-1 but 3b, 5a-c, and 6 were virtually inactive.

Synthesis and in vitro anti-HCV activity of β-D- and L-2′-deoxy-2′-fluororibonucleosides

Shi, Junxing,Du, Jinfa,Ma, Tianwei,Pankiewicz, Krzysztof W.,Patterson, Steven E.,Hassan, Abdalla E. A.,Tharnish, Phillip M.,McBrayer, Tamara R.,Lostia, Stefania,Stuyver, Lieven J.,Watanabe, Kyoichi A.,Chu, Chung K.,Schinazi, Raymond F.,Otto, Michael J.

, p. 875 - 879 (2007/10/03)

Based on the discovery of β-D-2′-deoxy-2′-fluorocytidine as a potent anti-hepatitis C virus (HCV) agent, a series of β-D- and L-2′-deoxy-2′-fluororibonucleosides with modifications at 5 and/or 4 positions were synthesized and evaluated for their in vitro activity against HCV and bovine viral diarrhea virus (BVDV). The introduction of the 2′-fluoro group was achieved by either fluorination of 2,2′-anhydronucleosides with hydrogen fluoride-pyridine or potassium fluoride, or a fluorination of arabinonucleosides with DAST. Among the 27 analogues synthesized, only the 5-fluoro compounds, namely β-D-2′- deoxy-2′,5-difluorocytidine (5), had anti-HCV activity in the subgenomic HCV replicon cell line, and inhibitory activity against ribosomal RNA. As β-D-N4-hydroxycytidine (NHC) had previously shown potent anti-HCV activity, the two functionalities of the N4-hydroxyl and the 2′-fluoro were combined into one molecule, yielding β-D-2′- deoxy-2′-fluoro-N4-hydroxycytidine (12). However, this nucleoside showed neither anti-HCV activity nor toxicity. All the L-forms of the analogues were devoid of anti-HCV activity. None of the compounds showed anti-BVDV activity, suggesting that the BVDV system cannot reliably predict anti-HCV activity in vitro. Copyright Taylor & Francis, Inc.

Modulation of CEACAM1 expression

-

Page/Page column 26, (2010/02/11)

Compounds, compositions and methods are provided for modulating the expression of CEACAM1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CEACAM1. Methods of using these compounds for modulation of CEACAM1 expression and for diagnosis and treatment of disease associated with expression of CEACAM1 are provided.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 10212-20-1