102-02-3 Usage
Description
PHENYLBIGUANIDE, also known as 1-Phenylbiguanide, is a member of the class of biguanides. It is a biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group. PHENYLBIGUANIDE acts as a 5-hydroxytryptamine receptor agonist and is known to increase extracellular dopamine release in rat nucleus accumbens in vivo. It is also used as a building block for the synthesis of heterocyclic compounds.
Uses
Used in Pharmaceutical Industry:
PHENYLBIGUANIDE is used as a 5-hydroxytryptamine receptor agonist for its ability to increase extracellular dopamine release in rat nucleus accumbens in vivo. This makes it a potential candidate for the development of treatments related to dopamine-related disorders.
Used in Chemical Synthesis:
PHENYLBIGUANIDE is used as a building block for the synthesis of heterocyclic compounds, which are important in various chemical and pharmaceutical applications. Its unique structure allows for the creation of a wide range of complex molecules with diverse properties and functions.
Purification Methods
Crystallise the biguanide from water or toluene. [Beilstein 12 H 370, 12 I 236, 12 III 807.]
Check Digit Verification of cas no
The CAS Registry Mumber 102-02-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 102-02:
(5*1)+(4*0)+(3*2)+(2*0)+(1*2)=13
13 % 10 = 3
So 102-02-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)
102-02-3Relevant articles and documents
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Schaefer,Bojanowski
, p. 364,365 (1972)
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NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE
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Page/Page column 60; 69, (2020/01/08)
Methods of treating diseases related to cGAS activation. Small molecule inhibitors of cGAS and pharmaceutical compositions and uses thereof in treating autoimmune diseases or inflammation.
Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents
Magri, Andrea,Reilly, Roisin,Scalacci, Nicolò,Radi, Marco,Hunter, Michael,Ripoll, Manon,Patel, Arvind H.,Castagnolo, Daniele
supporting information, p. 5372 - 5376 (2015/11/09)
The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.
