10191-61-4

Basic information

• Product Name: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT
• Synonyms: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT;CYANIMIDODITHIOCARBONIC ACID S-METHYL ESTER S-POTASSIUM SALT;Potassium methyl cyanoiminodithiocarbonate.;Cyanimidodithiocarbonic acid S-methyl ester;Cyanoimidodithiocarbonic acid S-methyl ester S-potassium salt;Cyanimidodithiocarbonic acid monomethyl estermonopotassium salt,98%;Potassium methyl cyanimidodithiocarbonate, Potassium (cyanoimino)(methylsulphanyl)methanethiolate, Potassium {[(methylthio)(sulphido)methylene]amino}(nitrilo)methane;Potassium methyl N-cyanocarbonodithioimidate 98%
• CAS NO: 10191-61-4
• Molecular Formula: C₃H₃N₂S₂*K
• Molecular Weight: 170.3
• Mol File: 10191-61-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-212 °C
• Boiling Point: 196.3°Cat760mmHg
• Flash Point: 72.5°C
• Appearance: Off-white to beige/Crystalline Powder
• Density: 1.332g/cm³
• Vapor Pressure: 0.401mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(10191-61-4)
• EPA Substance Registry System: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(10191-61-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 10191-61-4(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige crystalline powder

InChI:InChI=1/C3H4N2S2/c1-7-3(6)5-2-4/h1H3,(H,5,6)

Upstream product

• 13145-41-0 potassium cyanocarbonimidodithioate 
• 74-88-4 methyl iodide 
• 75-15-0 carbon disulfide 
• 420-04-2 CYANAMID 

Downstream Products

• 60093-28-9 (5-isopropyl-4-oxo-3-phenyl-thiazolidin-2-ylidene)-cyanamide 
• 60093-29-0 (5-isopropyl-4-oxo-3-m-tolyl-thiazolidin-2-ylidene)-cyanamide 
• 63238-21-1 [3-(2-nitro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 63238-11-9 4-Amino-2-methylthio-5-thiazol-(N,N-pentamethylencarboxamid) 
• 71466-79-0 3-imino-5-methylsulfanyl-3H-[1,2,4]thiadiazole-2-carboxylic acid methyl ester 
• 60093-08-5 (4-amino-2-methylsulfanyl-thiazol-5-yl)-(2,4,5-trichloro-phenyl)-methanone 
• 63238-15-3 4-Amino-N-phenyl-2-methylthio-5-thiazolcarboxanilid 
• 63238-23-3 [3-(2,4-dinitro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 49773-27-5 2-benzimidoyl-5-methylsulfanyl-[1,2,4]thiadiazol-3-ylideneamine 
• 60093-22-3 (4-oxo-2-m-tolyl-thiazolidin-2-ylidene)-cyanamide 
• 60093-21-2 [3-(3-chloro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 63238-08-4 4-amino-2-methylsulfanyl-thiazole-5-carboxylic acid dibenzylamide 
• 60093-27-8 [3-(4-methoxy-phenyl)-5-methyl-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 60093-25-6 (5-methyl-4-oxo-3-phenyl-thiazolidin-2-ylidene)-cyanamide 

Relevant articles and documents

Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors

A structure-activity relationship study unexpectedly showed that carbonothioates 4a and 4b, obtained by a unique alkaline hydrolysis of 2-alkylthio-oxazolines 3a and 3b, respectively, are a novel scaffold for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Derivatization of the carbonothioates enhanced inhibitory activity against IDO1 and cellular kynurenine production without cytotoxicity and led to the discovery of the related scaffolds carbonodithioates 5 and cyanocarbonimidodithioates 6 as IDO1 inhibitors. Incorporation of an OH group provided the most potent analogue 5i. UV-visible absorption spectroscopy of the Soret band, as well as docking and peptide mapping studies, suggested that these molecules bind to the heme in the active site of IDO1. Our unique IDO1 inhibitors are potential leads for future development.

Synthesis method of ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

The invention belongs to the technical field of pharmaceutical intermediates, and relates to a synthesis method of ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. The method includes the followingsteps that an aqueous solution of cyanamide is mixed with ethanol, carbon disulfide and a potassium hydroxide solution are added for reaction, and a precipitated solid is subjected to suction filtration and drying to obtain an intermediate A; the intermediate A is dissolved in a mixed solution of ethanol and water, an iodomethane ethanol solution is dropped for reaction, and an intermediate B isobtained through concentration and drying; the intermediate B, ethyl chloroacetate and triethylamine are subjected to a reflux reaction in ethanol, and the obtained solution is concentrated, washed and re-crystallized to obtain ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. The cost of raw materials is low, the yield of by-products is low, the product yield is high, and the method is suitablefor scale-up production.

Thiazolopyridine analogs of nalidixic acid. 2. Thiazolo[4,5-b]pyridines

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