101691-94-5

Basic information

• Product Name: 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN
• Synonyms: 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN;4-IODOMETHYLTETRAHYDROPYRAN;(4-TETRAHYDROPYRANYL)METHYL IODIDE;4-(Iodomethyl)tetrahydro-2H-pyrane;4-(Iodomethyl)tetrahydropyrane;4-(iodomethyl)oxane;2H-Pyran, tetrahydro-4-(iodomethyl)-
• CAS NO: 101691-94-5
• Molecular Formula: C₆H₁₁IO
• Molecular Weight: 226.06
• Mol File: 101691-94-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 229.1 °C at 760 mmHg
• Flash Point: 92.4 °C
• Appearance: /
• Density: 1.645 g/cm³
• Vapor Pressure: 0.107mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN(101691-94-5)
• EPA Substance Registry System: 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN(101691-94-5)

Safety Data

• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• Hazardous Substances Data: 101691-94-5(Hazardous Substances Data)

Usage

General Description

4-(Iodomethyl)tetrahydro-2H-pyran, also known as 4-Iodomethyltetrahydropyran, is a chemical compound with the molecular formula C6H11IO. It is a clear, colorless to pale yellow liquid with a faint odor and is mainly used as an intermediate in organic synthesis. 4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN is commonly employed in the production of pharmaceuticals and agrochemicals. It is also utilized as a building block in the preparation of various other organic compounds. Additionally, 4-(Iodomethyl)tetrahydro-2H-pyran is known for its potential as a reagent in chemical reactions, making it a versatile and useful compound in the field of organic chemistry.

InChI:InChI=1/C6H11IO/c7-5-6-1-3-8-4-2-6/h6H,1-5H2

Upstream product

• 132291-95-3 4-(methanesulfonyloxymethyl)tetrahydropyran 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 101691-65-0 toluene-4-sulfonic acid tetrahydropyran-4-ylmethyl ester 

Downstream Products

• 745053-49-0 (R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid 
• 1093307-19-7 5-(4-fluorophenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-4-(tributylstannyl)-1H-1,2,3-triazole 
• 1093307-22-2 1-((tetrahydro-2H-pyran-4-yl)methyl)-5-o-tolyl-4-(tributylstannyl)-1H-1,2,3-triazole 
• 1093304-02-9 1-acetyl-5-[5-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole 
• 1093307-23-3 1-(5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-5-o-tolyl-1H-1,2,3-triazol-4-yl)-1H-indazol-1-yl)ethanone 
• 1093307-24-4 2-fluoro-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-5-o-tolyl-1H-1,2,3-triazol-4-yl)benzonitrile 
• 1093304-16-5 5-[5-(2-methylphenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole 
• 1093304-13-2 5-[5-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-1,2,3-triazol-4-yl]-1H-indazole 
• 1003013-69-1 2-(4-methanesulfonyl-3-methyl-phenyl)-3-(tetrahydro-pyran-4-yl)-propionic acid 
• 1003013-70-4 2(R)-(4-methanesulfonyl-3-methyl-phenyl)-3-(tetrahydro-pyran-4-yl)-propionic acid 

Relevant articles and documents

CONDENSED RING HETEROCYCLIC COMPOUND

The ring-fused heterocyclic compound or a pharmaceutically acceptable salt thereof according to the present invention has a T-type calcium channel regulatory effect, and is useful, for example, as a medicament for treating and/or preventing pruritus. The present invention provides a ring-fused heterocyclic compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof and the like which has a T-type calcium channel regulatory effect and is useful as a therapeutic and/or preventive agent for pruritus, and the like. [wherein, R1 represents optionally substituted lower alkyl and the like, R2 represents optionally substituted lower alkyl and the like, R3 represents the formula (II): (wherein, n represents 0 or 1, R3a represents a hydrogen atom and the like, R3b represents a hydrogen atom and the like, and R3c represents a hydrogen atom and the like) and the like, Q represents a hydrogen atom and the like, and W1 represents a nitrogen atom and the like, W2 represents a nitrogen atom and the like]

Highly diastereoselective esterification of ketenes generated in situ from acyl chlorides with (R)-pantolactone derivatives

Our mechanistic investigations have revealed that Et3N is a key requirement for the highly diastereoselective formation of esters from the corresponding acyl chlorides with (R)-pantolactone via ketene-derived complexes. Furthermore, we have discovered that (R)-N-benzyl-pantolactam is a more effective chiral alcohol than (R)-pantolactone for the esterification of in situ generated ketenes. Ketene esterification with (R)-pantolactone derivatives is a powerful synthetic method for the synthesis of chiral α-arylpropionic acids. Our mechanistic investigations have revealed that Et3N is a key requirement for the predominant formation of ketenes from acyl chlorides, and (R)-N-benzylpantolactam was a much more effective chiral auxiliary.

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10);R5 and R6 are independently selected from H, alkyl and halogen;Y is R7(CH2)s or is absent; andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.