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  • 101363-10-4 Structure
  • Basic information

    1. Product Name: RUFLOXACIN
    2. Synonyms: AKOS NCG1-0068;8-FLUORO-9-(4-METHYL-PIPERAZIN-1-YL)-6-OXO-2,3-DIHYDRO-6H-1-THIA-3A-AZA-PHENALENE-5-CARBOXYLIC ACID;RUFLOXACIN;9-Fluom-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid;ISF-09334;Mones;Qari;Tebraxin
    3. CAS NO:101363-10-4
    4. Molecular Formula: C17H18FN3O3S
    5. Molecular Weight: 363.41
    6. EINECS: N/A
    7. Product Categories: ACTIVE PHARMACEUTICAL INGREDIENTS
    8. Mol File: 101363-10-4.mol
    9. Article Data: 1
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 574.6 °C at 760 mmHg
    3. Flash Point: 301.3 °C
    4. Appearance: /
    5. Density: 1.54
    6. Vapor Pressure: 4.81E-14mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 5.21±0.20(Predicted)
    11. CAS DataBase Reference: RUFLOXACIN(CAS DataBase Reference)
    12. NIST Chemistry Reference: RUFLOXACIN(101363-10-4)
    13. EPA Substance Registry System: RUFLOXACIN(101363-10-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101363-10-4(Hazardous Substances Data)

101363-10-4 Usage

Pharmaceutical Applications

A tricyclic fluoroquinolone formulated as the hydrochloride salt. It is inactive against Gram-positive cocci with MICs >2 mg/L. It displays weak activity in vitro against Enterobacteriaceae with the MIC for most species >1 mg/L. Activity against Ps. aeruginosa is poor (MIC 16–32 mg/L). After loading doses of 400 and 600 mg followed with 9 days of either 200 or 300 mg, mean peak plasma levels were around 4.5–7 mg/L, respectively. The mean apparent elimination halflife was 44 h. Approximately 50% is eliminated in the urine.It has been used in urinary tract infection and chronic prostatitis, but clinical experience is limited.

Check Digit Verification of cas no

The CAS Registry Mumber 101363-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,3,6 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 101363-10:
(8*1)+(7*0)+(6*1)+(5*3)+(4*6)+(3*3)+(2*1)+(1*0)=64
64 % 10 = 4
So 101363-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H

101363-10-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Rufloxacin

1.2 Other means of identification

Product number -
Other names MF 934

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101363-10-4 SDS

101363-10-4Relevant articles and documents

Quinolonecarboxylic Acids. 2. Synthesis and Antibacterial Evaluation of 7-Oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic Acids

Cecchetti, Violetta,Fravolini, Arnaldo,Fringuelli, Renata,Mascellani, Giuseppe,Pagella, Piergiuseppe,et al.

, p. 465 - 473 (2007/10/02)

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro antibacterial activity was evaluated.The 1,4-benzothiazine intermediates, which by Gould-Jacobs quinoline synthesis produced pyridobenzothiazine acids, were prepared by hydrolytic basic cleavage of substituted 2-aminobenzothiazoles and successive cyclocondensation with 1-bromo-2-chloroethane or alternatively with monochloroacetic acid, hence reduction by LiAlH4.The pyridobenzothiazine acids 10c, 30, and 31 show potent antibacterial activities against Gram-positive and Gram-negative pathogens.Structure-activity relationships are discussed.The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic acid (31) (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species (rat, dog, monkey, man).

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