1013036-55-9Relevant articles and documents
Reactions of in situ generated N-Boc nitrones with aromatic and heteroaromatic Grignard reagents: Application to the synthesis of zileuton
Guinchard, Xavier,Denis, Jean-Noel
, p. 2028 - 2031 (2008/09/19)
(Chemical Equation Presented) A new class of α-aromatic-N- hydroxylamines has been prepared by reaction of tert-butyl (phenylsulfonyl) alkyl-N-hydroxycarbamates with aromatic and heteroaromatic Grignard reagents. Reactions proceed via a base-assisted elimination of the phenylsulfonyl group leading to N-Boc nitrones. This methodology has been applied to the synthesis of zileuton.