101251-09-6 Usage
Description
4-Acetamidophenylboronic acid is an organic compound with the chemical formula C6H9NO3B. It is a white to light yellow crystalline powder that serves as a versatile building block in the synthesis of various organic compounds and pharmaceuticals.
Uses
1. Used in Pharmaceutical Industry:
4-Acetamidophenylboronic acid is used as a reactant for the synthesis of TpI2 kinase inhibitors, which are important in the development of treatments for various diseases.
2. Used in Chemical Research:
4-Acetamidophenylboronic acid is used as a reactant in the biological evaluation of modulators of the survival motor neuron protein, contributing to the understanding of motor neuron diseases and potential therapeutic interventions.
3. Used in Organic Synthesis:
4-Acetamidophenylboronic acid is used as a reactant in cross-coupling reactions with conjugated dienes, terminal alkenes, or diazoesters, enabling the synthesis of a wide range of organic compounds with diverse applications.
4. Used in Inorganic Chemistry:
4-Acetamidophenylboronic acid is used as a reactant in the synthesis of tetrabutylammonium trifluoroborates, which are useful in various chemical reactions and processes.
5. Used in Catalysis:
4-Acetamidophenylboronic acid is used as a reactant in rhodium-catalyzed cyanation reactions, which are important for the synthesis of various nitrogen-containing compounds.
6. Used in Cancer Treatment:
4-Acetamidophenylboronic acid is used in the synthesis of potent chrom-4-one inhibitors of the DNA-dependent protein kinase, which are utilized in radiotherapy and chemotherapy for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 101251-09-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,2,5 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 101251-09:
(8*1)+(7*0)+(6*1)+(5*2)+(4*5)+(3*1)+(2*0)+(1*9)=56
56 % 10 = 6
So 101251-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H10BNO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5,12-13H,1H3,(H,10,11)
101251-09-6Relevant articles and documents
Susceptibility to hydrolysis of phenylboronic pinacol esters at physiological pH
Achilli, Cesare,Ciana, Annarita,Fagnoni, Maurizio,Balduini, Cesare,Minetti, Giampaolo
, p. 137 - 139 (2013)
Boronic acids and their esters are highly considered compounds for the design of new drugs and drug delivery devices, particularly as boron-carriers suitable for neutron capture therapy. However, these compounds are only marginally stable in water. Hydrol
A method of preparing 4-aminophenylboronic acid derivatives
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Paragraph 0017; 0018; 0020, (2017/09/01)
The invention belongs to the technical field of medicine intermediates, and particularly relates to a method of preparing 4-aminophenylboronic acid derivatives. According to the method, 4-nitrophenylboronic acid is adopted as a raw material and subjected
Synthesis and biological activity of new 4-(Pyridin-4-yl)-(3-methoxy-5- methylphenyl)- 1H-pyrazoles derivatives as ROS Receptor tyrosine kinase inhibitors
Park, Byung Sun,El-deeb, Ibrahim M.,Yoo, Kyung Ho,Han, Dong Keun,Tae, Jin Sung,Lee, So Ha
, p. 3629 - 3634 (2013/01/16)
A series of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles (6a-k & 7a-l) has been rationally designed based on the structure of the lead compound KIST301080, a selective ROS receptor tyrosine kinase inhibitor, in order to study the activity of ROS of this new class of inhibitors. The compounds were synthesized and screened against ROS kinase, where compound 6h showed moderate inhibitory activity with an IC50 value of 6.25 μM. The study emphasized the importance of the acetonitrile group at the pyrazole ring and also the importance of having a hydrogen bond donor on the distal phenyl ring linked to the pyridine moiety.
