101-62-2 Usage
Description
4,4'-Dibenzamidine Oxide, also known as 4,4'-Oxydibenzamidine, is an organic compound characterized by two benzene rings connected by an oxydibenzamidine bridge. This bridge consists of two amidine functional groups (-NH-C(=NH)-NH-) separated by an oxygen atom. Although not widely recognized, this compound plays a significant role in research and chemical synthesis, serving as a building block or intermediate for the preparation of more complex organic molecules.
Uses
Used in Chemical Synthesis:
4,4'-Dibenzamidine Oxide is used as a building block for the synthesis of complex organic molecules. Its unique structure, featuring two amidine functional groups separated by an oxygen atom, allows for versatile chemical reactions and the formation of a wide range of compounds with diverse properties.
Used in Research:
In the field of research, 4,4'-Dibenzamidine Oxide serves as an important intermediate for the development of new chemical compounds and materials. Its unique structure and reactivity make it a valuable tool for exploring novel chemical pathways and understanding the properties of related compounds.
Used in Pharmaceutical Industry:
4,4'-Dibenzamidine Oxide is used as a precursor in the synthesis of pharmaceutical compounds. Its amidine functional groups can be further modified or reacted with other molecules to create potential drug candidates with therapeutic properties.
Used in Material Science:
In material science, 4,4'-Dibenzamidine Oxide can be used as a component in the development of new materials with specific properties. Its ability to form complex structures and participate in various chemical reactions makes it a promising candidate for creating materials with tailored characteristics for specific applications.
Overall, 4,4'-Dibenzamidine Oxide is a versatile compound with applications in various fields, including chemical synthesis, research, pharmaceuticals, and material science. Its unique structure and reactivity make it a valuable building block and intermediate for the development of new compounds and materials with diverse properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 101-62-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 101-62:
(5*1)+(4*0)+(3*1)+(2*6)+(1*2)=22
22 % 10 = 2
So 101-62-2 is a valid CAS Registry Number.
101-62-2Relevant articles and documents
Discovery of decamidine as a new and potent PRMT1 inhibitor
Zhang, Jing,Qian, Kun,Yan, Chunli,He, Maomao,Jassim, Brenson A.,Ivanov, Ivaylo,Zheng, Yujun George
supporting information, p. 440 - 444 (2017/03/08)
Protein arginine methyltransferase 1 (PRMT1) is a key player for the dynamic regulation of arginine methylation. Its dysregulation and aberrant expression are implicated in various pathological conditions, and a plethora of evidence suggests that PRMT1 inhibition is of significant therapeutic value. Herein, we reported the modification of a series of diamidine compounds with varied lengths in the middle alkyl linker for PRMT1 inhibition. Decamidine (2j), which possesses the longest linker in the series, displayed 2- and 4-fold increase in PRMT1 inhibition (IC50 = 13 μM), compared with furamidine and stilbamidine. The inhibitory activity toward PRMT1 was validated by secondary orthogonal assays. Docking studies showed that the increased activity is due to the extra interaction of the amidine group with the SAM binding pocket, which is absent when the linker is not long enough. These results provide structural insights into developing the amidine type of PRMT1 inhibitors.
