1006614-49-8Relevant articles and documents
Preparation method of phenyl-containing compound
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, (2022/01/04)
The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr
Preparation method of ticagrelor chiral intermediate
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Paragraph 0031; 0052;0053, (2019/04/06)
The invention discloses a preparation method of a ticagrelor chiral intermediate. The ticagrelor chiral intermediate is trans-(1R, 2S)-2-(3, 4-difluorophenyl) cyclopropylamine. The method includes thesteps: taking cyclopropylamine as a raw material; perfo
(1 R, 2 S) - 2 - (3, 4 - difluorophenyl) amine ·D - mandelic acid salt preparation method
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, (2018/02/04)
The invention discloses a preparation method of (1R,2S)-2-(3,4-difluorophenyl) rolicyprine.D-mandelate. The preparation method comprises the following steps: carrying out cyclopropanation on a compound shown in a formula V to obtain a compound shown in a formula IV; carrying out amide generation and Hofmann degradation to obtain a compound shown in a formula II; and performing salification with D-mandelic acid to obtain a compound shown in a formula I. The compound shown in the formula V is prepared in a way that a compound shown in a structure formula VI is subjected to CBS asymmetric reduction reaction, wherein a catalyst for the CBS asymmetric reduction reaction is a compound shown in a structural formula VII, and a reduction agent for the CBS asymmetric reduction reaction can be borane-tetrahydrofuran or borane-N,N-diethyl phenylamine.