100510-65-4 Usage
Description
6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE, also known as 6-Amino-3,3-dimethylindolin-2-one, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique structure, which includes an amino group, two methyl groups, and an oxo group attached to a dihydroindole scaffold.
Uses
Used in Pharmaceutical Industry:
6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE is used as a versatile reactant for the preparation of selective and potent aminoisoquinoline derivatives. These derivatives act as inhibitors of the mutant B-Raf pathway, which is implicated in various cancers. By targeting this pathway, these inhibitors can potentially help in the treatment of cancer.
Additionally, 6-AMINO-3,3-DIMETHYL-2-OXO-1,3-DIHYDRO-INDOLE is used in the synthesis of pentacyclic aurora kinase inhibitors. Aurora kinases are a family of serine/threonine protein kinases that play a crucial role in cell division and are often overexpressed in cancer cells. Inhibiting these kinases can lead to the suppression of tumor growth and the prevention of metastasis.
Check Digit Verification of cas no
The CAS Registry Mumber 100510-65-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,5,1 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100510-65:
(8*1)+(7*0)+(6*0)+(5*5)+(4*1)+(3*0)+(2*6)+(1*5)=54
54 % 10 = 4
So 100510-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O/c1-10(2)7-4-3-6(11)5-8(7)12-9(10)13/h3-5H,11H2,1-2H3,(H,12,13)
100510-65-4Relevant articles and documents
Pyrazolopyrimidine compounds and preparation method thereof, and applications in preparation of anti-cancer drugs
-
, (2020/04/17)
The invention provides a class of pyrazolopyrimidine compounds represented by a formula (I) or pharmaceutically acceptable salts thereof, and a preparation method thereof, and applications of the pyrazolopyrimidine compounds or the pharmaceutically accept
3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors
Li, Yanyang,Shi, Xiangfei,Xie, Ning,Zhao, Yanjin,Li, Shuxin
, p. 367 - 370 (2013/06/05)
A series of quinoline derivatives were designed and synthesized as tyrosine kinase inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, compound 10f was found to be a potent and selec
BENZAMIDE DERIVATIVE OR SALT THEREOF
-
Page/Page column 17; 32, (2008/06/13)
There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder
