100367-37-1

Basic information

• Product Name: 3-AMINO-4-BROMOPHENOL
• Synonyms: 3-AMINO-4-BROMOPHENOL;4-BroMo-3-aMinophenol;Phenol, 3-aMino-4-broMo-;3-AMINO-4-BROMOPHENO
• CAS NO: 100367-37-1
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.023
• Product Categories: Aromatic Halides (substituted)
• Mol File: 100367-37-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 300.1 °C at 760 mmHg
• Flash Point: 135.3 °C
• Appearance: /
• Density: 1.768
• Vapor Pressure: 0.000642mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.45±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-4-BROMOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-BROMOPHENOL(100367-37-1)
• EPA Substance Registry System: 3-AMINO-4-BROMOPHENOL(100367-37-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100367-37-1(Hazardous Substances Data)

Usage

Description

3-Amino-4-bromophenol, an organic compound with the molecular formula C6H6BrNO, is a substituted phenol characterized by the presence of an amino group and a bromine atom. It can be synthesized through the reaction of 3-nitrophenol with stannous chloride and hydrobromic acid. This versatile chemical is recognized for its applications in the production of dyes, pharmaceuticals, and as an intermediate in organic synthesis. However, it is also identified as a potential mutagen and a hazardous substance that necessitates careful handling and storage to prevent skin and eye irritation.

Uses

Used in Dye Production:
3-Amino-4-bromophenol is utilized as a key intermediate in the synthesis of various dyes, contributing to the coloration and stability of these products in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3-Amino-4-bromophenol serves as a crucial intermediate for the development of certain medications, playing a significant role in the synthesis of active pharmaceutical ingredients.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 3-Amino-4-bromophenol is employed in the preparation of a range of organic compounds, facilitating the creation of new chemical entities for various applications.

InChI:InChI=1/C6H6BrNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2

Upstream product

• 59557-92-5 2-bromo-5-methoxyaniline 
• 591-27-5 m-Hydroxyaniline 
• 78137-76-5 4-bromo-3-nitrophenol 

Downstream Products

• 591-27-5 m-Hydroxyaniline 
• 1155270-72-6 7-bromo-2,3-dihydropyrano[4,3,2-de]quinoline 
• 1155419-89-8 2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid 
• 1155270-71-5 7-bromo-5-chloro-2,3-dihydropyrano[4,3,2-de]quinoline 
• 1155270-69-1 8-bromo-5-hydroxy-4-(2-hydroxyethyl)quinolin-2(1H)-one 
• 1402714-51-5 methyl 2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetate 
• 1402714-51-5 methyl 2-(tert-butoxy)-2-((S)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetate 
• 1609581-21-6 5-(furo[3,2-c]pyridin-4-yloxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1609581-20-5 2-bromo-5-(furo[3,2-c]pyridin-4-yloxy)aniline 
• 1005782-80-8 N-[6-(3-amino-4-bromophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide 

Relevant articles and documents

Discovery of meta-amido bromophenols as new antitubercular agents

A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.

Polymer-anchored peroxo compounds of molybdenum and tungsten as efficient and versatile catalysts for mild oxidative bromination

A polymer supported peroxomolybdate(VI) compound of the type [MoO 2(O2)(CN)2]-PAN [PAN = poly(acrylonitrile)] (PANMo) was obtained by reacting H2MoO4 with 30% H 2O2 and the macromolecular ligand, PAN at near neutral pH. The macrocomplex has been characterized by elemental analysis (CHN and EDX analysis), spectral (IR, UV-Vis and 13C NMR, 95Mo NMR), thermal (TGA-DTG) as well as SEM studies. The catalytic activity of PANMo and its previously reported tungsten containing analog PANW, in oxidative bromination of organic substrates has been explored. The supported complexes could serve as efficient heterogeneous catalysts for the oxidative bromination of a variety of structurally diverse aromatic compounds, with H 2O2 as terminal oxidant, to afford bromo organics in impressive yields under environmentally clean conditions. The catalysts afforded regeneration and could be reused for a minimum of six reaction cycles.