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| CAS No.: | 83915-83-7 |
|---|---|
| Name: | Lisinopril |
| Molecular Structure: | |
 |
|
| Formula: | C21H31O5N3.2(H2O) |
| Molecular Weight: | 441.52 . |
| Synonyms: | (S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline;Prestwick_613;Tersif;(S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline;(S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate;Lisinal;Prinzide;Acercomp;Sinopril;Prinivil (TN);L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-;Loril;Lysinopril;(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenyl-propyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate;L-Proline, 1-(N(sup 2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-;Sinopryl;Renacor;Cipral;1-(N(sup 2)-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate;(S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline disulphate;L-Proline, 1-(N(sup 2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-, (S)-;Lisinopril· 2H2O;Lisinopril DiH2O; |
| EINECS: | 278-488-1 |
| Density: | 1.251 g/cm3 |
| Melting Point: | 148 °C |
| Boiling Point: | 666.4 °C at 760 mmHg |
| Flash Point: | 356.9 °C |
| Solubility: | H2O: ≥10 mg/mL |
| Appearance: | White to off-white crystalline powder |
| Hazard Symbols: |
 Xi,  Xn
|
| Risk Codes: | 20/21/22 |
| Safety: | 22-24/25-36 |
| PSA: | 132.96000 |
| LogP: | 2.26430 |
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Specification
The Lisinopril dihydrate with the cas number 83915-83-7, is also called (2S)-1-[(2S)-6-amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate, which is also it's IUPAC name, and it's system Names are (1) L-Proline, 1-(N(sup 2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)- (2) L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-. It belongs to the following product categories: (1)Drug bulk; (2)Active Pharmaceutical Ingredients; (3)All Inhibitors; (4)Inhibitors; (5)Intermediates & Fine Chemicals; (6)Pharmaceuticals; (7)API's; (8)Angiotensin and so on.
Physical properties about Lisinopril dihydrate are: (1)ACD/LogP: 1.19 ; (2)# of Rule of 5 Violations: 1 ; (3)#H bond acceptors: 8 ; (4)#H bond donors: 5 ; (5)#Freely Rotating Bonds: 13 ; (6)Polar Surface Area: 79.39Å2 ; (7)Flash Point: 356.9 °C ; (8)Enthalpy of Vaporization: 102.94 kJ/mol ; (9)Boiling Point: 666.4 °C at 760 mmHg ; (10)Vapour Pressure: 1.14E-18 mmHg at 25°C
Uses of Lisinopril dihydrate: This product lonely was used to treat with light hypertension or medium treatment and the curative effect is superior to Atenolol or Hydrochlorothiazide. When it is the same with metoprolol or or nifedipine when used to treat with severe hypertension. It is superior to captopril when it is used to treat with congestie heart failure, can increase left ventricular ejection fraction, improve patient ability and improve quality of life. At present, the product is second line drugs to treat with hypertension and congestie heart failure. This product is the lysine derivatives of with enalaprilat, powerful angiotensin converting enzyme inhibition. It can produce pharmacological effects without hepatic transformation function in vivo. Pharmacological effects occur later, but can maintain stably for a long time and. Adverse reaction include dizziness, headache, cough, nausea and diarrhea, heart palpitations, chest distress, lack of power, orthostatic hypotension, hypotension or rash, elevated blood neurological edema, potassium, rare blood urea nitrogen or elevated serum creatinine, about 5% patients need drug withdrawal due to adverse reactions.
When you are using this chemical, please be cautious about it as the following: It is quite harmful by inhalation, in contact with skin and if swallowed. When you are using this chemical, you should wear suitable protective clothing to prevent you from avoiding contact with skin and eyes.
You can still convert the following datas into molecular structure :
(1).SMILES: O=C(O)[C@H]2N(C(=O)[C@@H](N[C@H](C(=O)O)CCc1ccccc1)CCCCN)CCC2.O.O
(2).InChI:InChI=1/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1