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CAS No.: | 7421-40-1 |
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Name: | Carbenoxolone disodium |
Molecular Structure: | |
Formula: | C34H50 O7 . 2 Na |
Molecular Weight: | 614.80 |
Synonyms: | Olean-12-en-29-oicacid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, disodium salt, (3b,20b)- (9CI); Olean-12-en-30-oic acid, 3b-hydroxy-11-oxo-, hydrogensuccinate, disodium salt (7CI,8CI); 3-(Succinyloxy)glycyrrhetic acid disodiumsalt; Bioral; Carbenoxalone disodium salt; Carbenoxalone sodium; Carbenoxolonedisodium; Carbenoxolone disodium salt; Carbenoxolone sodium; Carbenoxolonesodium salt; Disodium glycyrrhetic acid hemisuccinate; Disodium glycyrrhetinylsuccinate; Duogastrone; Glycyrrhetic acid hydrosuccinate disodium salt;Glycyrrhetinic acid hydrogen succinate disodium salt; Glycyrrhetinic acidsuccinate disodium salt; Neogel; Pyrogastrone; Sanodin; Sodium carbenoxolone;Ulcus-Tablinen |
EINECS: | 231-044-0 |
Melting Point: | >275°C (dec.) |
Boiling Point: | 687.4oC at 760 mmHg |
Flash Point: | 211.6oC |
Solubility: | Soluble in water to 100 mM. |
Hazard Symbols: | Xn,Xi |
Risk Codes: | 22-36 |
Safety: | Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: blood pressure increase, change in blood potassium levels. Experimental reproductive effects. An anti-inflammatory agent used to treat gastric ulcers. When heated to decomposition it emits toxic fumes of Na2O. |
PSA: | 123.63000 |
LogP: | 4.15890 |
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orl-hmn TDLo:120 mg/kg/6 W:CVS,MET |
CMAJAX Canadian Medical Association Journal. 117 (1977),1155. | |
2. | orl-rat LD50:2450 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),263. | ||
3. | ipr-rat LD50:112 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710. | ||
4. | scu-rat LD50:1515 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710. | ||
5. | ipr-mus LD50:120 mg/kg | 21NDAB Symposium on Carbenoxolone Sodium Robson, J.M., andF.M. Sullivan, eds.,London, UK.: Butterworth,1968,6. | ||
6. | ivn-mus LD50:198 mg/kg | 21NDAB Symposium on Carbenoxolone Sodium Robson, J.M., andF.M. Sullivan, eds.,London, UK.: Butterworth,1968,6. | ||
7. | orl-dog LD50:3900 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710. | ||
8. | ipr-dog LD50:371 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),710. | ||
9. | scu-dog LD50:1060 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),263. | ||
10. | ivn-dog LD50:371 mg/kg |
| OYYAA2 O CARBENOXALONE, DISODIUM SALT (7421-40-1) has toxicity. Organism Test Type Route Reported Dose (Normalized Dose) Effect Source CARDIAC: PULSE RATE Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. BEHAVIORAL: TREMOR Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976. LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 263, 1976.
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