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| CAS No.: | 63516-07-4 |
|---|---|
| Name: | Flutropium bromide |
| Molecular Structure: | |
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| Formula: | C24H29BrFNO3 |
| Molecular Weight: | 496.47 |
| Synonyms: | Flutropium Bromide;Flutropium;8-Azoniabicyclo[3.2.1]Octane, 8-(2-Fluoroethyl)-3-[(Hydroxydiphenylacetyl)Oxy]-8-Methyl-, Bromide, (3-Endo,8-Syn)-;8-Azoniabicyclo[3.2.1]Octane, 8-(2-Fluoroethyl)-3-[(Hydroxydiphenylacetyl)Oxy]-8-Methyl-, Bromide, (Endo,Syn)-;Ba 598br;Flubron;Ba 598;Flutropiumbromid; |
| EINECS: | 1533716-785-6 |
| Melting Point: | 192-193° (dec); mp 198-199° (dec) |
| Safety: | Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, Br−, and Cl−. |
| PSA: | 46.53000 |
| LogP: | 0.53800 |
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Chemistry
Chemistry informtion about Flutropium Bromide Hydrate (CAS NO.63516-07-4) is:
IUPAC Name: Acetyloxy-[5'-(Acetyloxymercurio)-3',6'-Dihydroxy-3-Oxospiro[2-Benzofuran-1,9'-Xanthene]-4'-Yl]Mercury
Synonyms: Flutropium Bromide ; Flutropium ; 8-Azoniabicyclo[3.2.1]Octane, 8-(2-Fluoroethyl)-3-[(Hydroxydiphenylacetyl)Oxy]-8-Methyl-, Bromide, (3-Endo,8-Syn)- ; 8-Azoniabicyclo[3.2.1]Octane, 8-(2-Fluoroethyl)-3-[(Hydroxydiphenylacetyl)Oxy]-8-Methyl-, Bromide, (Endo,Syn)- ; Ba 598br ; Flubron ; Ba 598 ; Flutropiumbromid
Molecular Formula: C24H29BrFNO3
Molecular Weight: 478.39
Following is the molecular structure of Flutropium Bromide Hydrate (CAS NO.63516-07-4) is:
Uses
Flutropium Bromide Hydrate (CAS NO.63516-07-4) is a quaternary ammonium antimuscarinic with bronchodilator properties that has been tried in the treatment of respiratory-tract.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 53mg/kg (53mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. | |
| mouse | LD50 | intravenous | 11mg/kg (11mg/kg) | behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: dyspnea behavioral: ataxia | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986. |
| mouse | LD50 | oral | 760mg/kg (760mg/kg) | behavioral: convulsions or effect on seizure threshold behavioral: ataxia lungs, thorax, or respiration: dyspnea | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986. |
| mouse | LD50 | subcutaneous | 228mg/kg (228mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. | |
| rat | LD50 | intraperitoneal | 77mg/kg (77mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. | |
| rat | LD50 | intravenous | 12500ug/kg (12.5mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. | |
| rat | LD50 | oral | 740mg/kg (740mg/kg) | behavioral: convulsions or effect on seizure threshold behavioral: ataxia lungs, thorax, or respiration: dyspnea | Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1348, 1986. |
| rat | LD50 | subcutaneous | 615mg/kg (615mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. |
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, Br−, and Cl−.