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| CAS No.: | 361-09-1 |
|---|---|
| Name: | Sodium cholate |
| Article Data: | 2 |
| Molecular Structure: | |
|
|
|
| Formula: | C24H39NaO5 |
| Molecular Weight: | 430.56 |
| Synonyms: | 17-(1-Methyl-3-carboxypropyl)etiocholane-3;17-beta-(1-methyl-3-carboxypropyl)etiocholane-3alpha,7alpha,12alpha-triol;3,7,12-trihydroxy-,(3-alpha,5-beta,7-alpha,12-alpha)-cholan-24-oicaci;3,7,12-trihydroxy-,(3alpha,5beta,7alpha,12alpha)-cholan-24-oicaci;3,7,12-Trihydroxy-5-chloanicacid;3,7,12-trihydroxy-cholan-24-oicacid(3-alpha,5-beta,7-alpha,12-alpha);3-alpha,7-alpha,12-alpha-trihydroxycholansaeure; |
| EINECS: | 206-643-5 |
| Density: | 0.999 at 20.09℃ |
| Melting Point: | 198oC |
| Boiling Point: | 583.9 °C at 760 mmHg |
| Flash Point: | 321 °C |
| Solubility: | 150 g/L (20 °C) in water |
| Appearance: | white to off-white powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 24/25-36-26 |
| PSA: | 100.82000 |
| LogP: | 2.11400 |
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Chemistry
Molar mass: 430.55 g/mol
Flash Point: 321 °C
Boiling Point: 583.9 °C at 760 mmHg
Vapour Pressure: 4.59E-16 mmHg at 25°C
Water solubility: 150 g/L (20°C)
Appearance: white to off-white powder
Structure of Sodium cholate(361-09-1):
Synonyms: Cholic acid sodium salt; Sodium (3a,5b,7a,12a)-3,7,12-trihydroxycholan-24-oate;3,7,12-Trihydroxy-5-chloanicacid;3,7,12-trihydroxy-,(3-alpha,5-beta,7-alpha,12-alpha)-cholan-24-oicaci
Product Categories: Anionic Surfactants;Functional Materials;Steroids;Surfactants;Bile Acids;Biochemistry;Carboxylate (Surfactants)
Uses
Sodium cholate(361-09-1) has been used for prevention of gallstone generation. And known sodium cholate(361-09-1) can be used for anti-inflammatory, too.
Production
Method 1, acids' precipitation method
Cattle (or sheep, pigs) bile [95% ethanol] → [heating reflux extraction] extract [Filter] → [distillation] extract [pH3-4] → bile acids in crude
or :Chicken (geese, ducks) bile [NaOH, boiled] → saponification solution [HCl, pH2] → total bile acid
Preparation of bile acid
Crude bile acids [Sour] → [95% ethanol] → [heating] [pH8-8.5, activated carbon] → bile acid
Methods 2, ethanol extraction
Gall ointment [carbon] → dealing with gall bladder cream
Dealing with gall bladder cream [95% ethanol] → filtrate [Recovery of ethanol] → bile salt crude
Methods 3, salting method
Khan, crude bile salts [washing] → [drying, crushing] [95% ethanol extract] → [bleaching, evaporated] bile salts Boutique
Methods 4, to cholesterol as the raw material
Primary bile acid synthesis of cholesterol in a variety of enzymes, and through a series of catabolism and ultimately the formation of conjugated primary bile acid (cholic acid and chenodeoxycholic acid).
Toxicity Data With Reference
| 1. | orl-mus LD50:2400 mg/kg | ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences.(103)(1985),29. | ||
| 2. | ipr-mus LD50:164 mg/kg | ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the National Hygiene Sciences.(103)(1985),29. | ||
| 3. | ivn-mus LD50:200 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 90 (1952),18. | ||
| 4. | ivn-rbt LDLo:50 mg/kg | ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. 52 (1926),779. |
Consensus Reports
Safety Profile
Hazard Codes: Xi
Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
24: Avoid contact with skin
25: Avoid contact with eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
Specification
Skin: Get medical aid. Should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing and shoes.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Inhalation: Remove from exposure and move to fresh air immediately.Give artificial respiration While not breathing.
Ingestion: Wash mouth out with water,and get medical aid immediately.
Notes to Physician: Treat supportively and symptomatically.
Stability and Reactivity of Sodium cholate(361-09-1):
Chemical Stability: Stable.
Incompatibilities with Other Materials: Strong oxidizing agents.
Conditions to Avoid: Incompatible materials,exposure to moist air or water.
Hazardous Decomposition Products: Carbon dioxide,carbon monoxide.