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| CAS No.: | 3092-17-9 |
|---|---|
| Name: | Midodrine hydrochloride |
| Article Data: | 8 |
| Molecular Structure: | |
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| Formula: | C12H18N2O4.HCl |
| Molecular Weight: | 290.74 |
| Synonyms: | (+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride;N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide hydrochloride (1:1);2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride;Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride;Metligene;Alphamine; |
| EINECS: | 256-148-3 |
| Melting Point: | 192-193 °C |
| Boiling Point: | 529.9 °C at 760 mmHg |
| Flash Point: | 274.3 °C |
| Appearance: | Crystalline Solid |
| Hazard Symbols: |
 T
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| Risk Codes: | 25 |
| Safety: | 45 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 93.81000 |
| LogP: | 1.70530 |
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Specification
The Midodrine hydrochloride, with the CAS registry number 3092-17-9, is also known as 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride. It belongs to the product categories of Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C12H18N2O4.HCl and molecular weight is 290.74. What's more, its systematic name is N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide hydrochloride (1:1). This chemcial is a phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.
Physical properties of Midodrine hydrochloride are: (1)ACD/LogP: -0.664; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.25; (4)ACD/LogD (pH 7.4): -0.84; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 6.96; (9)#H bond acceptors: 6; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 51.24 Å2; (13)Flash Point: 274.3 °C; (14)Enthalpy of Vaporization: 84.75 kJ/mol; (15)Boiling Point: 529.9 °C at 760 mmHg; (16)Vapour Pressure: 4.64E-12 mmHg at 25°C.
Uses of Midodrine hydrochloride: it can be used to produce {[2-(2,5-dimethoxy-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-carbamic acid ethyl ester. It will need reagent NEt3 and solvents tetrahydrofuran, H2Owith the reaction time of 1 hour. The yield is about 95%.
![Midodrine hydrochloride can be used to produce {[2-(2,5-dimethoxy-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-carbamic acid ethyl ester](/UserFilesUpload/Uses of Midodrine hydrochloride.jpeg)
When you are using this chemical, please be cautious about it as the following:
This chemcial is toxic if swallowed. In case of accident or if you feel unwell, you should seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.O=C(NCC(O)c1cc(OC)ccc1OC)CN
(2)Std. InChI: InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
(3)Std. InChIKey: MGCQZNBCJBRZDT-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 1333, 1995. | |
| mouse | LD50 | intraperitoneal | 171mg/kg (171mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| mouse | LD50 | intravenous | 56200ug/kg (56.2mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| mouse | LD50 | oral | 246mg/kg (246mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| mouse | LD50 | subcutaneous | 170mg/kg (170mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| rat | LD50 | intraperitoneal | 31300ug/kg (31.3mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| rat | LD50 | intravenous | 18200ug/kg (18.2mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| rat | LD50 | oral | 68800ug/kg (68.8mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. | |
| rat | LD50 | subcutaneous | 51mg/kg (51mg/kg) | Drugs in Japan Vol. -, Pg. 1152, 1990. |