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| CAS No.: | 309-36-4 |
|---|---|
| Name: | Methohexital Sodium |
| Molecular Structure: | |
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| Formula: | C14H18 N2 O3 . Na |
| Molecular Weight: | 284.32 |
| Synonyms: | 2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, sodium salt (9CI);Barbituricacid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium deriv. (6CI,7CI);Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium salt (8CI);Brevimytal;Brevimytal sodium;Brevital sodium;Brietal sodium;Enallynymalsodium;Methohexitone sodium;Sodium methohexital;Sodiummethohexitone;2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2-propen-1-yl)-, sodium salt (1:1); |
| EINECS: | 206-217-9 |
| Density: | g/cm3 |
| Boiling Point: | 382.1°Cat760mmHg |
| Flash Point: | 184.9°C |
| Safety: | Poison by intravenous and implant routes. Human systemic effects by intravenous route: blood pressure lowering, gastrointestinal effects, and allergic dermatitis. An FDA proprietary drug. Caution: Excessive use may lead to addiction or habituation. Allergenic effects by intravenous route. When heated to decomposition it emits toxic fumes of Na2O and NOx. See also BARBITURATES. |
| PSA: | 57.69000 |
| LogP: | 1.35910 |
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Chemistry
The IUPAC name of Methohexital Sodium (CAS NO.309-36-4):
Sodium 5-hex-3-yn-2-yl-1-methyl-4,6-dioxo-5-prop-2-enylpyrimidin-2-olate
Synonyms: Methohexital sodium ; Brevimytal .;Sodiummethohexital ; Methohexitone sodium ; Brevital sodium ; Enallynymal sodium
CAS: 309-36-4
EINECS: 206-217-9
Molecular Formula: C14H18N2O3Na
Molecular Structure:
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Molecular Weight: 284.2861 g/mol
Flash Point: 184.9 °C
Boiling Point: 382.1 °C at 760 mmHg
General Description: White powder.
Air & Water Reactions: Water soluble.
Uses
Methohexital is primarily used to induce anesthesia, and is generally provided as a sodium salt (i.e. methohexital sodium). It is only used in hospital or similar settings, under strict supervision.[citation needed] It has been commonly used to induce deep sedation, "twilight sleep" or general anesthesia for oral surgery and dentistry. It is also used to induce anesthesia prior to ECT(electroconvulsive therapy).
Toxicity Data With Reference
The toxicity of Methohexital Sodium (CAS NO.309-36-4):
| 1. | ivn-wmn TDLo:25 µg/kg:CVS,GIT,SKN | JOSUA9 Journal of Oral Surgery. 30 (1972),906. | ||
| 2. | ivn-rat LD50:24,890 µg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292. | ||
| 3. | imp-rat LD50:33 mg/kg | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75. | ||
| 4. | ivn-mus LD50:33,600 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 12 (1976),247. | ||
| 5. | ivn-dog LD50:21,500 µg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292. | ||
| 6. | imp-dog LD50:25 mg/kg | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75. | ||
| 7. | ivn-rbt LD50:8640 µg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 89 (1955),292. | ||
| 8. | imp-rbt LD50:10 mg/kg | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,75. |
Safety Profile
The Fire Hazard of Methohexital Sodium (CAS NO.309-36-4): Flash point data are not available for methohexital sodium, but methohexital sodium is probably combustible. Poison by intravenous and implant routes. Human systemic effects by intravenous route: blood pressure lowering, gastrointestinal effects, and allergic dermatitis. An FDA proprietary drug. Caution: Excessive use may lead to addiction or habituation. Allergenic effects by intravenous route. When heated to decomposition it emits toxic fumes of Na2O and NOx. See also BARBITURATES.