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| CAS No.: | 27262-48-2 |
|---|---|
| Name: | Levobupivacaine hydrochloride |
| Article Data: | 5 |
| Molecular Structure: | |
|
|
|
| Formula: | C18H29ClN2O |
| Molecular Weight: | 324.894 |
| Synonyms: | 2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, (2S)- (9CI);2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride,(S)-;2',6'-Pipecoloxylidide, 1-butyl-, monohydrochloride, (-)- (8CI);(-)-Bupivacaine monohydrochloride;(S)-(-)-Bupivacaine monohydrochloride;Chirocaine;Popscaine;Levobupivacaine HCL; |
| EINECS: | 1308068-626-2 |
| Melting Point: | 254 °C (dec.)(lit.) |
| Boiling Point: | 423.4 °C at 760 mmHg |
| Flash Point: | 209.9 °C |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 T+,  Xn
|
| Risk Codes: | 26/27/28-20/21/22-28 |
| Safety: | 22-36/37/39-45-36/37-53 |
| Transport Information: | UN 2811 6.1/PG 2 |
| PSA: | 23.55000 |
| LogP: | 4.74080 |
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Chemistry
Molecular structure of Levobupivacaine hydrochloride (CAS NO.27262-48-2) is:
Product Name: Levobupivacaine hydrochloride
CAS Registry Number: 27262-48-2
IUPAC Name: (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride
Molecular Weight: 324.88866 [g/mol]
Molecular Formula: C18H29ClN2O
H-Bond Donor: 2
H-Bond Acceptor: 2
Melting Point: 254 °C (dec.)(lit.)
Flash Point: 209.9 °C
Enthalpy of Vaporization: 67.78 kJ/mol
Boiling Point: 423.4 °C at 760 mmHg
Vapour Pressure: 2.24E-07 mmHg at 25°C
Product Categories: Pharmaceutical Raw Materials;Active Pharmaceutical Ingredients
Uses
Levobupivacaine hydrochloride (CAS NO.27262-48-2) can be used in pain relief.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rabbit | LD50 | intravenous | 5100ug/kg (5.1mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. | |
| rabbit | LD50 | oral | 18mg/kg (18mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. | |
| rabbit | LD50 | parenteral | 207mg/kg (207mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. | |
| rat | LD50 | subcutaneous | 63mg/kg (63mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. |
Safety Profile
Safty information about Levobupivacaine hydrochloride (CAS NO.27262-48-2) is:
Hazard Codes: 
T+,
Xn
Risk Statements: 26/27/28-20/21/22-28
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R28:Very toxic if swallowed.
Safety Statements: 22-36/37/39-45-36/37-53
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
S53:Avoid exposure - obtain special instructions before use.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TK6125000
Specification
Levobupivacaine hydrochloride , its cas register number is 27262-48-2. It also can be called Levobupivacaine ; Levobupivacaine hydrochloride [USAN] ; (S)-1-Butyl-2',6'-pipecoloxylidide monohydrochloride ; (S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride ; Bupicaine hydrochloride (-) ; Chirocaine ; Levobupivacaine HCl ; Levobupivacaine hydrochloride ; 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)- ; 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, (2S)- .It is a white crystalline powder.