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| CAS No.: | 27164-46-1 |
|---|---|
| Name: | Cefazolin sodium salt |
| Article Data: | 6 |
| Molecular Structure: | |
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| Formula: | C14H14N8O4S3. Na |
| Molecular Weight: | 476.496 |
| Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-,monosodium salt (8CI);3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid sodium salt;Acef;Ancef;Atirin;Biazolina;Bor-Cefazol;Cefacidal;Cefazil;Cefazoliin;Cefazolin sodium;Cefazoline sodium;Cephazolin sodium;Cephazolin sodiumsalt;Firmacef;Gramaxin;Kefzol;Lampocef;Liviclina;Monosodium cafazolin;Reflin;SKF 41558;Sodium cefazolin;Sodium cephazolin;Totacef;Zolicef;Cefazolin sodium salt; |
| EINECS: | 248-278-4 |
| Melting Point: | 190 °C |
| Solubility: | 50 mg/mL in water |
| Appearance: | White to off-white powder |
| Hazard Symbols: |
 Xi,  Xn
|
| Risk Codes: | 20/21/22-36/37/38-42/43 |
| Safety: | 22-36/37 |
| PSA: | 237.76000 |
| LogP: | -1.64200 |
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Specification
1. Introduction of Cefazolin sodium salt
Cefazolin sodium salt is one kind of white or almost white powder. For being a kind of white to off-white powder, it is stable chemically but is incompatible with strong oxidizing agents. The IUPAC name of it is sodium 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. In addition, its product categories are including Active Pharmaceutical Ingredients; API; Antibiotics for Research and Experimental Use; beta-Lactams (Antibiotics for Research and Experimental Use); Biochemistry; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; A - KResearch Essentials. The Classification Code of it is Antibacterial [systemic]; Antibiotics; Drug / Therapeutic Agent; Human Data; Reproductive Effect.
2. Properties of Cefazolin sodium salt
Physical properties about Cefazolin sodium salt are:
(1)ACD/LogP: 1.13; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 12; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 226.14; (7)Exact Mass: 476.011958; (8)MonoIsotopic Mass: 476.011958.
3. Structure Descriptors of Cefazolin sodium salt
(1)Canonical SMILES: CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]
(2)InChI: InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1
(3)InChIKey: FLKYBGKDCCEQQM-UHFFFAOYSA-M
4. Toxicity of Cefazolin sodium salt
Below are the toxicity information of this chemical:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 2200mg/kg (2200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. | |
| dog | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Chemotherapy Vol. 18, Pg. 528, 1970. |
| human | TDLo | intramuscular | 14mg/kg/D (14mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971. |
| mouse | LD50 | intraperitoneal | 6200mg/kg (6200mg/kg) | Drugs in Japan Vol. 6, Pg. 404, 1982. | |
| mouse | LD50 | intravenous | 3900mg/kg (3900mg/kg) | Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973. | |
| mouse | LD50 | oral | > 11gm/kg (11000mg/kg) | Chemotherapy Vol. 18, Pg. 528, 1970. | |
| mouse | LD50 | subcutaneous | 7600mg/kg (7600mg/kg) | Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973. | |
| rabbit | LD50 | intravenous | 2500mg/kg (2500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979. | |
| rabbit | LD50 | subcutaneous | > 6gm/kg (6000mg/kg) | Chemotherapy Vol. 18, Pg. 528, 1970. | |
| rat | LD50 | intraperitoneal | 7400mg/kg (7400mg/kg) | Drugs in Japan Vol. 6, Pg. 404, 1982. | |
| rat | LD50 | intravenous | 2760mg/kg (2760mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Chemotherapy Vol. 35(Suppl, |
| rat | LD50 | oral | > 11gm/kg (11000mg/kg) | Chemotherapy Vol. 18, Pg. 528, 1970. | |
| rat | LD50 | subcutaneous | 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971. |
| women | TDLo | intravenous | 660mg/kg/11D- (660mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Nephron. Vol. 45, Pg. 72, 1987. |
5. Safety information of Cefazolin sodium salt
For one thing, it is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health. If by inhalation, in contact with skin and if swallowed, it will be very dangerous. Besides, this chemical may cause sensitisation by inhalation and skin contact. Therefore, you should wear suitable protective clothing and gloves. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and then remember not to breathe dust.
6. Uses of Cefazolin sodium salt
As to its usage, it is usually used as the semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. It also used as an antibacterial. It is one kind of first-generation cephalosporins.