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Basic Information
CAS No.: 23668-11-3
Name: Pactamycin
Article Data: 6
Molecular Structure:
Molecular Structure of 23668-11-3 (Pactamycin)
Formula: C28H38 N4 O8
Molecular Weight: 558.632
Synonyms: Pactamycin (7CI);NSC 52947;
Density: 1.38g/cm3
Boiling Point: 784.2°Cat760mmHg
Flash Point: 428.1°C
Hazard Symbols: T+
Risk Codes: 28-36/37/38
Safety: Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
PSA: 194.68000
LogP: 1.91870
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Chemistry

Product Name: Pactamycin (23668-11-3)


Molecular Formula: C28H38N4O8
Molecular Weight: 558.70g/mol
Mol File: 23668-11-3.mol
Boiling point: 784.2°C at 760mmHg
Flash Point: 428.1°C
Density: 1.38g/cm3
Synonyms of  Pactamycin (23668-11-3): AI3-51038; NSC 52947 ; NSC-52947 ; Pactamycin ; SK 27773 ; 5-((3-Acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl 2-hydroxy-6-methylbenzoate (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))- ; U 15800 ; U-15800 ; Upjohn culture 135bt .

Uses

  Pactamycin (23668-11-3) is produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.

Toxicity Data With Reference

1.    

mmo-eug 150 mg/L

    NEOLA4    Neoplasma. 19 (1972),579.
2.    

dni-eug 150 mg/L

    NEOLA4    Neoplasma. 19 (1972),579.
3.    

dni-rat-ipr 6 mg/kg

    RCOCB8    Research Communications in Chemical Pathology and Pharmacology. 11 (1975),311.
4.    

ivn-rat LD50:1400 µg/kg

    85ERAY    Antibiotics: Origin, Nature, and Properties. 2 (1978),1420.
5.    

orl-mus LD50:10 mg/kg

    UPJOH*    Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6).
6.    

ipr-mus LD50:32 mg/kg

    CNCRA6    Cancer Chemotherapy Reports. 30 (1963),9.
7.    

ivn-mus LD50:16 mg/kg

    85ERAY    Antibiotics: Origin, Nature, and Properties. 2 (1978),1420.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Specification

 Pactamycin (23668-11-3) is a amorphous powder. Sol in ethanol, chloroform, methylene chloride, benzene, ether.