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CAS No.: | 23668-11-3 |
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Name: | Pactamycin |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C28H38 N4 O8 |
Molecular Weight: | 558.632 |
Synonyms: | Pactamycin (7CI);NSC 52947; |
Density: | 1.38g/cm3 |
Boiling Point: | 784.2°Cat760mmHg |
Flash Point: | 428.1°C |
Hazard Symbols: | T+ |
Risk Codes: | 28-36/37/38 |
Safety: | Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
PSA: | 194.68000 |
LogP: | 1.91870 |
Product Name: Pactamycin (23668-11-3)
Molecular Formula: C28H38N4O8
Molecular Weight: 558.70g/mol
Mol File: 23668-11-3.mol
Boiling point: 784.2°C at 760mmHg
Flash Point: 428.1°C
Density: 1.38g/cm3
Synonyms of Pactamycin (23668-11-3): AI3-51038; NSC 52947 ; NSC-52947 ; Pactamycin ; SK 27773 ; 5-((3-Acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl 2-hydroxy-6-methylbenzoate (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))- ; U 15800 ; U-15800 ; Upjohn culture 135bt .
Pactamycin (23668-11-3) is produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.
1. | mmo-eug 150 mg/L | NEOLA4 Neoplasma. 19 (1972),579. | ||
2. | dni-eug 150 mg/L | NEOLA4 Neoplasma. 19 (1972),579. | ||
3. | dni-rat-ipr 6 mg/kg | RCOCB8 Research Communications in Chemical Pathology and Pharmacology. 11 (1975),311. | ||
4. | ivn-rat LD50:1400 µg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1420. | ||
5. | orl-mus LD50:10 mg/kg | UPJOH* Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6). | ||
6. | ipr-mus LD50:32 mg/kg | CNCRA6 Cancer Chemotherapy Reports. 30 (1963),9. | ||
7. | ivn-mus LD50:16 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 2 (1978),1420. |
Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Pactamycin (23668-11-3) is a amorphous powder. Sol in ethanol, chloroform, methylene chloride, benzene, ether.