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Basic Information
CAS No.: 2188-68-3
Name: Lycorine hydrochloride
Molecular Structure:
Molecular Structure of 2188-68-3 (Lycorine hydrochloride)
Formula: C16H17NO4.HCl
Molecular Weight: 323.776
Synonyms: 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride, (1S,2S,12bS,12cS)- (9CI);Galanthan-1,2-diol, 3,12-didehydro-9,10-[methylenebis(oxy)]-, hydrochloride, (1a,2b)-;Lycoran-1a,2b-diol, 3,3a-didehydro-, hydrochloride (8CI);Licorin hydrochloride;
Melting Point: 210-212oC
Boiling Point: 477.4 °C at 760 mmHg
Flash Point: 242.5 °C
Appearance: fine crystal powder.
Hazard Symbols:
Risk Codes: 25
Safety: 45
Transport Information: UN 2811 6.1/PG 3
PSA: 62.16000
LogP: 0.68650
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  • 99% up by HPLC Lycorine hydrochloride Lycorine HCL 2188-68-3

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  • Lycorine Hydrochloride

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    2188-68-3

    Lycorine Hydrochloride

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Chemistry

Molecular Structure:

Molecular Formula: C16H18ClNO4
Molecular Weight: 323.7714 
Systematic Name: (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1)
Synonyms of Lycorine hydrochloride (CAS NO.2188-68-3): Galanthan-1,2-diol, 3-12-didehydro-9,10-(methylenebis(oxy))-, hydrochloride, (1-alpha,2-beta)- ; Licorin hydrochloride ; Lycorine HCl ; Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride
CAS NO: 2188-68-3
Classification Code: Peptidyl transferaseCell Signaling and Neuroscience ; Enzyme Inhibitors by Enzyme ; Gene Regulation and Expression ; P to ; RNA-Protein Translation Inhibitors 
Flash Point: 242.5 °C
Enthalpy of Vaporization: 78.09 kJ/mol
Boiling Point: 477.4 °C at 760 mmHg
Vapour Pressure: 6.37E-10 mmHg at 25°C

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 21, 1958.
mouse LD50 intravenous 123mg/kg (123mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 21, 1958.
mouse LD50 oral 230mg/kg (230mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 21, 1958.

Safety Profile

Hazard Codes of Lycorine hydrochloride (CAS NO.2188-68-3): ToxicT
Risk Statements: 25 
R25: Toxic if swallowed.
Safety Statements: 45 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3