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CAS No.: | 19396-06-6 |
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Name: | POLYOXIN B |
Article Data: | 1 |
Molecular Structure: | |
Formula: | C17H25N5O13 |
Molecular Weight: | 507.411 |
Synonyms: | Allofuranuronicacid,5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-,monocarbamate (ester), b-D- (8CI);Polyoxin B (7CI);Milpan;Polar;Polar (antibiotic); |
EINECS: | 243-024-9 |
Density: | 1.774 g/cm3 |
Melting Point: | 150-153 °C (decomp) |
Boiling Point: | 595.71°C (rough estimate) |
PSA: | 309.98000 |
LogP: | -4.84660 |
IUPAC Name: (2S)-2-[[(2S,3S,4S)-2-Amino-5-carbamoyloxy-3,4-dihydroxypentanoyl]amino]-2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-
2,4-dioxopyrimidin-1-yl]oxolan-2-yl]acetic acid
Synonyms: Polyoxin B ; 5-(2-Amino-5-o-carbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid ; 5-[[2-Amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid ; Allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd;polyoxinal ; Ro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-,monocarbamate(ester),bet ; Piomycin ; Polyoxin AL(JMAF)
CAS NO: 19396-06-6
Molecular Formula: C17H25N5O13
Molecular Weight: 507.41
Molecular Structure:
EINECS: 243-024-9
Mol File: 19396-06-6.mol
Index of Refraction: 1.669 Surface Tension: 112.1 dyne/cm Density: 1.774 g/cm3
Storage temp: 0-6°C
Melting point:180 °C
Appearance: Polyoxin AL (CAS NO.19396-06-6) is colorless needle crystal.
Solubility: Polyoxin AL (CAS NO.19396-06-6) is soluble in water, insoluble in methanol, ethanol, acetone, chloroform, benzene and ether and other organic solvents.
Stability:Polyoxin AL (CAS NO.19396-06-6) is stable to the ultraviolet light, acid solution, neutral solution, , instability in alkaline solution
Polyoxin AL (CAS NO.19396-06-6) is broad-spectrum antibiotics, fungicides, with absorption and conduction. Its mechanism is to interfere with cell wall chitin biosynthesis. and is mainly used for prevention and control of wheat powdery mildew, black spot ginseng, tobacco brown spot disease, downy mildew of cucumber, melon fusarium wilt, rice sheath blight, Alternaria leaf disease, strawberry and grape Botrytis cinerea, tree diseases such as multiple dry sheath kinds of fungus diseases.
Slope of sand control bacteria strains [10 ~ 14d, 26 °C ] → shake-flask seed [36 ~ 48h, 28 °C ] → Seed pot seeds [24h, 28 °C ] → fermentation [90 ~ 120h, 28°C ] put cans , fermentation broth acidified (pH = 3 ~ 4) → concentrated → drying → packing
1. | orl-rat LD50:14,665 mg/kg | FMCHA2 Farm Chemicals Handbook .(Meister Publishing,Willoughy, OH.: )1983,C192. | ||
2. | orl-mus LD50:15,638 mg/kg | FMCHA2 Farm Chemicals Handbook .(Meister Publishing,Willoughy, OH.: )1983,C192. | ||
3. | ivn-mus LD50:200 mg/kg | 85DGAU Catalog of Teratogenic Agents. 5 (1981),245. |
Poison by intravenous route. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.