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| CAS No.: | 1786-81-8 |
|---|---|
| Name: | Propitocaine hydrochloride |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C13H20N2O.HCl |
| Molecular Weight: | 256.776 |
| Synonyms: | Citanest hydrochloride;L 67;L 67hydrochloride;Prilocaine chloride;Propitocainehydrochloride;Xylonest;a-(Propylamino)-2-methylpropionanilide hydrochloride;Prilocaine HCL;Propanamide,N-(2-methylphenyl)-2-(propylamino)-, monohydrochloride (9CI);o-Propionotoluidide,2-(propylamino)-, monohydrochloride (8CI);2-(Propylamino)-o-propionotoluididehydrochloride;Citanest Plain; |
| EINECS: | 217-244-0 |
| Melting Point: | 168-170oC |
| Boiling Point: | 361.6 °C at 760 mmHg |
| Flash Point: | 134.3 °C |
| Appearance: | White or off white crystalline powder |
| PSA: | 41.13000 |
| LogP: | 3.58750 |
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Chemistry
Molecular Structure of CITANEST HYDROCHLORIDE(1786-81-8):
IUPAC Name: N-(2-methylphenyl)-2-(propylamino)propanamide hydrochloride
Molecular Formula:C13H21ClN2O
Molecular Weight:256.771640 g/mol
Appearance:white or almost white crystalline powder
Flash Point:134.3 °C
Enthalpy of Vaporization:60.74 kJ/mol
Boiling Point:361.6 °C at 760 mmHg
Vapour Pressure:2.05E-05 mmHg at 25 °C
EINECS:217-244-0
Synonyms of CITANEST HYDROCHLORIDE(1786-81-8):
2-(propylamino)-o-propionotoluidide hydrochloride;2-(propylamino)-o-propionotoluididmonohydrochloride;alpha-propylamine-2-methyl-propionanilidehydrochloride;citanesthydrochloride;l-67hydrochloride;n-(2-methylphenyl)-2-(propylamino)-propanamidmonohydrochloride;prilocainechloride;xylonest
Categories of CITANEST HYDROCHLORIDE(1786-81-8):
Active Pharmaceutical Ingredients;Sodium channel
Uses
CITANEST HYDROCHLORIDE(1786-81-8) is a local anesthetic used for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.
Toxicity Data With Reference
| 1. | ipr-rat LD50:148 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),692. | ||
| 2. | scu-rat LD50:790 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),692. | ||
| 3. | ivn-rat LD50:56,600 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),692. | ||
| 4. | ipr-mus LD50:30 mg/kg | 29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,99. | ||
| 5. | scu-mus LD50:632 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),692. | ||
| 6. | ivn-mus LD50:55 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),692. |
Safety Profile
The safety information of CITANEST HYDROCHLORIDE(1786-81-8) is as follows:
RTECS:UG5775000
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits very toxic fumes of HCl and NOx.