Benzenepropanoic acid, 2-phenylethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 2-phenylethyl ester
• CAS No.: 28049-10-7
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Mol file: 28049-10-7.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, 2-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 2-phenylethyl ester

There total 18 articles about Benzenepropanoic acid, 2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenylethanol (60-12-8) + 3-Phenylpropionic acid (501-52-0) → 3-phenylpropionic acid 2-phenylethyl ester (28049-10-7)

Guidance literature:

With monolith-SO₃H; In toluene; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1246/bcsj.20210266

Reference yield: 99.0%

2-phenylethanol (60-12-8) + 2-oxo-4-phenylbutyric acid (710-11-2) → 3-phenylpropionic acid 2-phenylethyl ester (28049-10-7)

Guidance literature:

With 3-nitro(diacetoxyiodo)benzene; In dichloromethane; at 20 ℃; for 4h; Reagent/catalyst; chemoselective reaction; Sealed tube; Darkness;

DOI:10.1021/acs.orglett.8b02466

Reference yield: 94.0%

2-phenylethanol (60-12-8) + 3-phenylpropanoic acid methyl ester (103-25-3) → 3-phenylpropionic acid 2-phenylethyl ester (28049-10-7)

Guidance literature:

With chloro-trimethyl-silane; diphenylammonium trifluoromethanesulfonate; In toluene; at 80 - 110 ℃; for 24h;

DOI:10.1016/S0040-4039(00)00821-2

upstream raw materials:

2-phenylethanol

3-Phenylpropionic acid

β-phenylpropionyl peroxide

3,3,6,6-tetra(phenethyl)-1,2,4,5-tetraoxan

Refernces

• 1、 Ichihara, Shuta,Ishida, Moeka,Ito, Ryo,Kato, Ayumu,Monguchi, Yasunari,Nakamura, Shinji,Park, Kwihwan,Sajiki, Hironao,Takada, Hitoshi,Wakayama, Fumika,Yamada, Tsuyoshi,Yamada, Yutaro. "Esterification or Thioesterification of Carboxylic Acids with Alcohols or Thiols Using Amphipathic Monolith-SO3H Resin". . p. 2702 - 2710. Retrieved 2022/01/19.
• 2、 Topf, Christoph,Vielhaber, Thomas. "Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol". . . Retrieved 2021/07/10.