Imidazole, 1-(o-nitrophenyl)- (8CI)

Base Information

• Chemical Name: Imidazole, 1-(o-nitrophenyl)- (8CI)
• CAS No.: 23309-16-2
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.173
• Mol file: 23309-16-2.mol

Synonyms:1-(2-Nitrophenyl)-1H-imidazole;(2-Nitrophenyl)imidazole;

Chemical Property of Imidazole, 1-(o-nitrophenyl)- (8CI)

Chemical Property:

• Melting Point: 97-98℃
• Boiling Point: 375 °C at 760 mmHg
• PKA: 4.65±0.10(Predicted)
• Flash Point: 180.6 °C
• PSA: 63.64000
• Density: 1.33 g/cm³
• LogP: 2.30370

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2-nitrophenyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazole, 1-(o-nitrophenyl)- (8CI)

There total 13 articles about Imidazole, 1-(o-nitrophenyl)- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1H-imidazole (288-32-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1-(2-nitrophenyl)-1H-imidazole (23309-16-2)

Guidance literature:

With 1,2,3-Benzotriazole; potassium tert-butylate; copper(l) iodide; In dimethyl sulfoxide; at 110 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2007.04.061

Reference yield: 99.0%

1H-imidazole (288-32-4) + o-nitroiodobenzene (609-73-4) → 1-(2-nitrophenyl)-1H-imidazole (23309-16-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201000149

Reference yield: 99.0%

1H-imidazole (288-32-4) + 2-Chloronitrobenzene (88-73-3) → 1-(2-nitrophenyl)-1H-imidazole (23309-16-2)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 - 110 ℃;

DOI:10.1021/jo901462g

upstream raw materials:

1H-imidazole

ortho-nitrofluorobenzene

2-Chloronitrobenzene

2-nitrophenyl bromide

Downstream raw materials:

2-bromo-1-(2-nitrophenyl)-1H-imidazole

imidazo[1,2-a]quinoxaline-4-(5H)-one

Refernces

• 1、 Cui, Jian-Lan,Wang, Ning,Wang, Xiao,Yu, Si-Yuan,Zhong, Cong-Shan. "A green and practical reduction of N-(4-chlorophenyl)-2-nitroaniline and its derivatives to corresponding N-substituted-benzene-1,2-diamines using thiourea dioxide". supporting information. . Retrieved 2020/01/22.
• 2、 Dindarloo Inaloo, Iman,Majnooni, Sahar,Eslahi, Hassan,Esmaeilpour, Mohsen. "N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst". . p. 13266 - 13278. Retrieved 2020/10/07.