Technology Process of Cyclopropanecarboxylic acid, 1-amino-, 1,1-dimethylethyl ester
There total 4 articles about Cyclopropanecarboxylic acid, 1-amino-, 1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: sodium hydroxide / ethanol
3.1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 2 h / Inert atmosphere; Reflux
3.2: 5 h / Reflux
4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 6 h / 20 °C
With
diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00544
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol
2.1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 2 h / Inert atmosphere; Reflux
2.2: 5 h / Reflux
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 6 h / 20 °C
With
diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.7b00544