N-(2-aminoethyl)-N-methylcyclohexanamine

Base Information

• Chemical Name: N-(2-aminoethyl)-N-methylcyclohexanamine
• CAS No.: 14256-69-0
• Molecular Formula: C9H20N2
• Molecular Weight: 156.271
• Hs Code.: 2921300090
• European Community (EC) Number: 809-178-1
• Mol file: 14256-69-0.mol

Synonyms:N-(2-aminoethyl)-N-methylcyclohexanamine;14256-69-0;245487-33-6;N*1*-Cyclohexyl-N*1*-methyl-ethane-1,2-diamine;N1-cyclohexyl-N1-methylethane-1,2-diamine;N'-cyclohexyl-N'-methylethane-1,2-diamine;N1-Cyclohexyl-N1-methyl-ethane-1,2-diamine;N-cyclohexyl-N-methylethane-1,2-diamine;MFCD06446846;(2-aminoethyl)cyclohexylmethylamine;SCHEMBL3186493;FNZNHTIBNDAHFH-UHFFFAOYSA-N;AMY19046;BBL011822;STK500901;AKOS000150946;NS-01219;CS-0216301;FT-0650801;FT-0706786;EN300-39273;AB01002140-01;A885178

Chemical Property of N-(2-aminoethyl)-N-methylcyclohexanamine

Chemical Property:

• PSA: 29.26000
• LogP: 1.90990
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 156.162648646
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-aminoethyl)-N-methylcyclohexanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCN)C1CCCCC1

Technology Process of N-(2-aminoethyl)-N-methylcyclohexanamine

There total 5 articles about N-(2-aminoethyl)-N-methylcyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(cyclohexyl(methyl)amino)acetonitrile (96517-08-7) → N-cyclohexyl-N-methylethane-1,2-diamine (14256-69-0)

Guidance literature:

With diethyl ether; ammonia; nickel; at 125 ℃; under 73550.8 - 91938.4 Torr; Hydrogenation;

DOI:10.1021/ja01214a012

Reference yield:

N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methylethane-1,2-diamine (14256-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogen sulfite; water / beim Erwaermen anschliessend mit Kaliumcyanid

2: Raney nickel; diethyl ether; ammonia / 125 °C / 73550.8 - 91938.4 Torr / Hydrogenation

With diethyl ether; ammonia; water; nickel; sodium hydrogensulfite;

DOI:10.1021/ja01214a012

Reference yield:

1-nitroethylene (3638-64-0,26618-70-2) + N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methylethane-1,2-diamine (14256-69-0)

Guidance literature:

Multistep reaction; (i), (ii) LiAlH₄, ether;

DOI:10.1002/hlca.19600430703

upstream raw materials:

2-(cyclohexyl(methyl)amino)acetonitrile

1-nitroethylene

N-methylcyclohexylamine

2-(2-bromoethyl)isoindoline-1,3-dione

Downstream raw materials:

N-Methyl-N-cyclohexyl-N'-<2-hydroxy-aethyl>-aethylendiamin

<2-(Cyclohexyl-methyl-amino)-aethyl>-guanidin

Refernces

• 1、 -. "N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position". . . Retrieved 2008/06/13.