5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile
• CAS No.: 1232780-81-2
• Molecular Formula: C₁₀H₆F₂N₄
• Molecular Weight: 220.181
• Mol file: 1232780-81-2.mol

Synonyms:

Chemical Property of 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile

There total 1 articles about 5-Amino-1-(3,5-difluorophenyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethoxymethylenemalononitrile (123-06-8) + (3,5-difluorophenyl)hydrazine (134993-88-7) → C10H6F2N4 (1232780-81-2)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2016.02.050

Reference yield:

C10H6F2N4 (1232780-81-2) → C15H14F2N6

Guidance literature:

Multi-step reaction with 4 steps

1: 110 °C

2: trichlorophosphate / 130 °C

3: triethylamine / tetrahydrofuran / 20 - 60 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2016.02.050

Reference yield:

C10H6F2N4 (1232780-81-2) → C20H22F2N6O2

Guidance literature:

Multi-step reaction with 3 steps

1: 110 °C

2: trichlorophosphate / 130 °C

3: triethylamine / tetrahydrofuran / 20 - 60 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2016.02.050

upstream raw materials:

Ethoxymethylenemalononitrile

(3,5-difluorophenyl)hydrazine

Refernces