PF-06273340

Base Information

• Chemical Name: PF-06273340
• CAS No.: 1402438-74-7
• Molecular Formula: C₂₃H₂₂ClN₇O₃
• Molecular Weight: 479.926
• Mol file: 1402438-74-7.mol

Synonyms:

Chemical Property of PF-06273340

Chemical Property:

• Density: 1.47±0.1 g/cm3(Predicted)

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

PF06273340 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PF-06273340

There total 14 articles about PF-06273340 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H35ClF3N7O4Si → PF-06273340 (1402438-74-7)

Guidance literature:

C₃₁H₃₅ClF₃N₇O₄Si; With potassium carbonate; In methanol; at 20 ℃; for 16h;

With trifluoroacetic acid; at 50 ℃; for 5h;

Reference yield:

C38H46ClN7O5Si → PF-06273340 (1402438-74-7)

Guidance literature:

C₃₈H₄₆ClN₇O₅Si; With trifluoroacetic acid; at 50 ℃; for 3h; Inert atmosphere;

With potassium carbonate; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00850

Reference yield:

C44H50N6O4Si → PF-06273340 (1402438-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: citric acid / tetrahydrofuran; water / 5 h / 20 °C / Inert atmosphere

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 2 h / 25 °C / Inert atmosphere

3.1: trifluoroacetic acid / 3 h / 50 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; citric acid; In tetrahydrofuran; water; ethyl acetate;

DOI:10.1021/acs.jmedchem.6b00850

upstream raw materials:

2-(5-chloropyridin-2-yl)acetic acid

(5-aminopyridin-3-yl){7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-2-[(2,4-dimethoxybenzyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone

2-chloro-7H-pyrrolo[2,3-d]pyrimidine

2-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

Refernces

• 1、 -. "PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS". . . Retrieved 2012/10/18.