(S)-2-methyl-4-aminononane hydrochloride

Base Information

• Chemical Name: (S)-2-methyl-4-aminononane hydrochloride
• CAS No.: 129603-19-6
• Molecular Formula: C₁₀H₂₃N*ClH
• Molecular Weight: 193.76
• Mol file: 129603-19-6.mol

Synonyms:

Chemical Property of (S)-2-methyl-4-aminononane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methyl-4-aminononane hydrochloride

There total 6 articles about (S)-2-methyl-4-aminononane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(S)-2-methyl-4-(tert. butoxycarbonylamino)nonane (129603-13-0) → (S)-2-methyl-4-aminononane hydrochloride (129603-19-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃;

DOI:10.1055/s-1990-26900

Reference yield:

((E)-(R)-1-Isobutyl-hex-2-enyl)-carbamic acid tert-butyl ester (131064-84-1) → (S)-2-methyl-4-aminononane hydrochloride (129603-19-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃;

DOI:10.1021/jm00111a027

Reference yield:

(2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal (116662-96-5) → (S)-2-methyl-4-aminononane hydrochloride (129603-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hexamethyldisilazane / tetrahydrofuran

2: HCl / ethyl acetate / 0 °C

With hydrogenchloride; potassium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jm00111a027

upstream raw materials:

(S)-2-methyl-4-(tert. butoxycarbonylamino)nonane

((E)-(R)-1-Isobutyl-hex-2-enyl)-carbamic acid tert-butyl ester

(2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal

((Z)-(R)-1-Isobutyl-hex-2-enyl)-carbamic acid tert-butyl ester

Refernces

• 1、 Heimbrook,Saari,Balishin,Fisher,Friedman,Kiefer,Rotberg,Wallen,Oliff. "Gastrin releasing peptide antagonists with improved potency and stability". . p. 2102 - 2107. Retrieved 2007/10/02.