(E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide
• CAS No.: 60672-33-5
• Molecular Formula: C₁₆H₁₈N₂O₂S
• Molecular Weight: 302.397
• Mol file: 60672-33-5.mol

Synonyms:

Chemical Property of (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide

There total 6 articles about (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

toluene-4-sulfonic acid hydrazide (1576-35-8) + 4-n-methylphenylacetylene (766-97-2) → (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide (60672-33-5)

Guidance literature:

With [(THD-Dipp)AuOTf]; In neat (no solvent); at 100 ℃; regioselective reaction; Green chemistry;

DOI:10.1002/adsc.201500658

Reference yield: 92.0%

para-methylacetophenone (122-00-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → (E)-4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide (60672-33-5)

Guidance literature:

In hexane;

DOI:10.1021/acs.orglett.5b00398

Reference yield: 90.0%

para-methylacetophenone (122-00-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide (60672-33-5)

Guidance literature:

In methanol; at 60 ℃;

DOI:10.1021/acs.joc.9b02018

upstream raw materials:

para-methylacetophenone

toluene-4-sulfonic acid hydrazide

1-(1-azidovinyl)-4-methyl benzene

p-toluenesulfonyl chloride

Downstream raw materials:

1-(4-methoxybenzyl)-3-methyl-2-(1-(p-tolyl)vinyl)benzene

4-(3-methyl-2-(1-(p-tolyl)vinyl)phenyl)morpholine

5-tert-butyl-1,3-dimethyl-2-(1-p-tolylvinyl)benzene

1,1-di(p-tolyl)ethylene

Refernces

• 1、 Baell, Jonathan B.,Feng, Jiajun,He, Tiantong,Huang, Fei,Xie, Yuxing,Yu, Yang. "I2-Promoted [4 + 2] cycloaddition of: In situ generated azoalkenes with enaminones: Facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines". supporting information. p. 9483 - 9493. Retrieved 2020/12/15.
• 2、 Lamaa, Diana,Messe, Estelle,Gandon, Vincent,Alami, Mouad,Hamze, Abdallah. "Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System". supporting information. p. 8708 - 8712. Retrieved 2019/11/03.