[2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-4-Morpholinylphosphinic Acid

Base Information

• Chemical Name: [2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-4-Morpholinylphosphinic Acid
• CAS No.: 308367-90-0
• Molecular Formula: C₁₃H₂₁N₆O₄P
• Molecular Weight: 356.321
• Mol file: 308367-90-0.mol

Synonyms:

Chemical Property of [2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-4-Morpholinylphosphinic Acid

Chemical Property:

• Boiling Point: 625.4±65.0 °C(Predicted)
• PKA: 4.25±0.10(Predicted)
• Density: 1?+-.0.1 g/cm3(Predicted)
• Solubility.: Water

Purity/Quality:

97% ^*data from raw suppliers

[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-4-morpholinylphosphinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: [2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-4-morpholinylphosphinic Acid is an intermediate in the synthesis of Tenofovir Phosphate (T018510), a metabolite of Tenofovir (T018500).

Technology Process of [2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-4-Morpholinylphosphinic Acid

There total 1 articles about [2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-4-Morpholinylphosphinic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + tenofovir (147127-20-6) → C13H21N6O4P (308367-90-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In water; tert-butyl alcohol; Heating;

DOI:10.1080/15257770701508067

upstream raw materials:

morpholine

tenofovir

Refernces