1,6-dibromoisoquinoline

Base Information

• Chemical Name: 1,6-dibromoisoquinoline
• CAS No.: 1254514-00-5
• Molecular Formula: C₉H₅Br₂N
• Molecular Weight: 286.953
• Mol file: 1254514-00-5.mol

Synonyms:

Chemical Property of 1,6-dibromoisoquinoline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6-dibromoisoquinoline

There total 3 articles about 1,6-dibromoisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-1-chloroisoquinoline (205055-63-6) → 1,6-dibromoisoquinoline (1254514-00-5)

Guidance literature:

With trimethylsilyl bromide; In acetonitrile; Reflux;

Reference yield:

6-bromo-isoquinoline (34784-05-9) → 1,6-dibromoisoquinoline (1254514-00-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 - 30 °C

2: trichlorophosphate / 0.5 h / 75 - 85 °C

3: trimethylsilyl bromide / acetonitrile / Reflux

With trimethylsilyl bromide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; acetonitrile;

Reference yield:

6-bromoisoquinoline nitrogen oxide (223671-16-7) → 1,6-dibromoisoquinoline (1254514-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 0.5 h / 75 - 85 °C

2: trimethylsilyl bromide / acetonitrile / Reflux

With trimethylsilyl bromide; trichlorophosphate; In acetonitrile;

upstream raw materials:

6-bromo-isoquinoline

6-bromoisoquinoline nitrogen oxide

6-bromo-1-chloroisoquinoline

Downstream raw materials:

6-bromo-1-methylisoquinoline

Refernces