Technology Process of tert-butyl 4-(2-(3-(2,6-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)ethyl)piperazine-1-carboxylate
There total 7 articles about tert-butyl 4-(2-(3-(2,6-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)ethyl)piperazine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hypochlorite; tetrabutylammonium sulfate / dichloromethane; water / 1.37 h / 10 - 30 °C / Large scale reaction
2: water; sodium hydroxide / methanol / 1.5 h / 20 - 30 °C / Large scale reaction
3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.68 h / -5 - 26 °C / Large scale reaction
With
sodium hypochlorite; di-isopropyl azodicarboxylate; water; tetrabutylammonium sulfate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
3: Mitsunobu reaction;
DOI:10.1021/op100113j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 11.21 h / 20 - 30 °C / Large scale reaction
2: thionyl chloride; triethylamine / toluene / 3.58 h / -6 - 10 °C / Large scale reaction
3: sodium hypochlorite; tetrabutylammonium sulfate / dichloromethane; water / 1.37 h / 10 - 30 °C / Large scale reaction
4: water; sodium hydroxide / methanol / 1.5 h / 20 - 30 °C / Large scale reaction
5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.68 h / -5 - 26 °C / Large scale reaction
With
sodium hypochlorite; thionyl chloride; di-isopropyl azodicarboxylate; water; tetrabutylammonium sulfate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
5: Mitsunobu reaction;
DOI:10.1021/op100113j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 45 °C / 3087.28 - 3604.44 Torr / Large scale reaction
2: tetrahydrofuran / 11.21 h / 20 - 30 °C / Large scale reaction
3: thionyl chloride; triethylamine / toluene / 3.58 h / -6 - 10 °C / Large scale reaction
4: sodium hypochlorite; tetrabutylammonium sulfate / dichloromethane; water / 1.37 h / 10 - 30 °C / Large scale reaction
5: water; sodium hydroxide / methanol / 1.5 h / 20 - 30 °C / Large scale reaction
6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.68 h / -5 - 26 °C / Large scale reaction
With
sodium hypochlorite; thionyl chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; tetrabutylammonium sulfate; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
6: Mitsunobu reaction;
DOI:10.1021/op100113j
