erythro-Methylphenidate hydrochloride

Base Information

• Chemical Name: erythro-Methylphenidate hydrochloride
• CAS No.: 29419-96-3
• Molecular Formula: C₁₄H₁₉NO₂*ClH
• Molecular Weight: 269.771
• Mol file: 29419-96-3.mol

Synonyms:

Chemical Property of erythro-Methylphenidate hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-Methylphenidate hydrochloride

There total 15 articles about erythro-Methylphenidate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (R*,R*)-7-phenyl-1-azabicyclo[4.2.0]octan-8-one → methylphenidate hydrochloride (298-59-9,19262-68-1,23644-60-2,23655-65-4,29419-95-2,29419-96-3,29419-97-4,56502-30-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo982214t

Reference yield: 95.0%

methanol (67-56-1) + 2-phenyl-2-(piperidin-2-yl)acetic acid (1076192-92-1,54631-24-2,744954-37-8) → methylphenidate hydrochloride (298-59-9,19262-68-1,23644-60-2,23655-65-4,29419-95-2,29419-96-3,29419-97-4,56502-30-8)

Guidance literature:

methanol; 2-phenyl-2-(piperidin-2-yl)acetic acid; With hydrogenchloride; at 69.4 ℃;

With Trimethyl orthoacetate; at 60 - 63 ℃; Product distribution / selectivity;

Reference yield: 89.0%

methanol (67-56-1) + threo-ritalinic acid (1076192-92-1,54631-24-2,744954-37-8) → threo-methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride (298-59-9,19262-68-1,23644-60-2,23655-65-4,29419-95-2,29419-96-3,29419-97-4,56502-30-8)

Guidance literature:

methanol; threo-ritalinic acid; thionyl chloride; In water; ethyl acetate; at 0 - 20 ℃;

With hydrogenchloride; In isopropyl alcohol; at 0 - 25 ℃; for 4 - 6h;

upstream raw materials:

methanol

threo-ritalinic acid

dl-threo-methylphenidate

methyl (R*)-2-phenyl-2-((S*)-piperidin-2-yl)acetate

Downstream raw materials:

l-threo-methylphenidate / dibenzoyl L-tartaric acid

2-phenyl-2-(piperidin-2-yl)acetic acid

Refernces

• 1、 Sadanandan, Sandhya,Gupta, Dharmendra Kumar. "Changing stereoselectivity and regioselectivity in copper(i)-catalyzed 5-: Exo cyclization by chelation and rigidity in aminoalkyl radicals: Synthesis towards diverse bioactive N-heterocycles". . p. 3350 - 3365. Retrieved 2020/03/06.
• 2、 -. "PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF". Page/Page column 0345-0347. . Retrieved 2015/05/26.