Technology Process of (2S,3R)-N-benzoyl-3-tert-butoxycarbonylmethyl-4-oxo proline tert-butyl ester
There total 5 articles about (2S,3R)-N-benzoyl-3-tert-butoxycarbonylmethyl-4-oxo proline tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / dimethylformamide-dineopentylacetal / benzene / Heating
2: 76 percent / RuO2*xH2O, NaIO4 / CCl4; CHCl3; H2O / 6 h / Ambient temperature
3: 99 percent / 5 Angstroem molecular sieves / benzene / 16 h / Ambient temperature
4: 1.) K2CO3, 2.) acetic acid / 1.) acetonitrile, room temperature, 120 h, 2.) H2O, CHCl3, room temperature, 26 h.
With
ruthenium(IV) oxide; sodium periodate; 5A molecular sieve; potassium carbonate; acetic acid; N,N-dimethylformamide dineopentyl acetal;
In
tetrachloromethane; chloroform; water; benzene;
DOI:10.1016/S0040-4020(97)00190-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / 5 Angstroem molecular sieves / benzene / 16 h / Ambient temperature
2: 1.) K2CO3, 2.) acetic acid / 1.) acetonitrile, room temperature, 120 h, 2.) H2O, CHCl3, room temperature, 26 h.
With
5A molecular sieve; potassium carbonate; acetic acid;
In
benzene;
DOI:10.1016/S0040-4020(97)00190-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / RuO2*xH2O, NaIO4 / CCl4; CHCl3; H2O / 6 h / Ambient temperature
2: 99 percent / 5 Angstroem molecular sieves / benzene / 16 h / Ambient temperature
3: 1.) K2CO3, 2.) acetic acid / 1.) acetonitrile, room temperature, 120 h, 2.) H2O, CHCl3, room temperature, 26 h.
With
ruthenium(IV) oxide; sodium periodate; 5A molecular sieve; potassium carbonate; acetic acid;
In
tetrachloromethane; chloroform; water; benzene;
DOI:10.1016/S0040-4020(97)00190-7